Background: DNA CpG island hypermethylation causes gene silencing and is a common
event in prostate carcinogenesis and progression. We investigated its role as a possible …

Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation
events in prostate cancer. However, DNA methylation profiles have not been compared on a …

Altered genome methylation is a hallmark of human malignancies. In this study, high-
throughput analyses of concordant gene methylation and expression events were performed …

Aberrant DNA methylation plays a significant role in nearly all human cancers and may
contribute to disease progression to advanced phenotypes. Study of advanced prostate …

DNA methyltransferases (DNMTs) regulate gene expression by methylating cytosine
residues within CpG dinucleotides. Aberrant methylation patterns have been shown in a …

Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic
epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to …

Background The prostate gland is the most common site of cancer and the second leading
cause of cancer mortality in American men. It is well known that epigenetic alterations such …

With approximately 1.4 million men annually diagnosed with prostate cancer (PCa)
worldwide, PCa remains a dreaded threat to life and source of devastating morbidity. In …

Aberrant DNA methylation is one of the hallmarks of carcinogenesis and has been
recognized in cancer cells for more than 20 years. The role of DNA methylation in malignant …

Prostate cancer (CaP) is mostly composed of luminal-like differentiated cells, but contains a
small subpopulation of basal cells (including stem-like cells), which can proliferate and …