Global DNA hypomethylation in prostate cancer development and progression: a systematic review
R Zelic, V Fiano, C Grasso, D Zugna… - Prostate cancer and …, 2015 - nature.com
Background: The role of global DNA methylation in prostate cancer (PCa) remains largely
unknown. Our aim was to summarize evidence on the role of global DNA hypomethylation in …
unknown. Our aim was to summarize evidence on the role of global DNA hypomethylation in …
Functional epigenomics identifies genes frequently silenced in prostate cancer
In many cases, silencing of gene expression by CpG methylation is causally involved in
carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor …
carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor …
[HTML][HTML] Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding …
Background Current diagnostic tools for prostate cancer lack specificity and sensitivity for
detecting very early lesions. DNA methylation is a stable genomic modification that is …
detecting very early lesions. DNA methylation is a stable genomic modification that is …
[HTML][HTML] Genome-wide association analysis reveals regulation of at-risk loci by DNA methylation in prostate cancer
Q Liu, G Liu, DT Martin, YT Xing… - Asian Journal of …, 2021 - journals.lww.com
Epigenetic changes are potentially important for the ontogeny and progression of tumors but
are not usually studied because of the complexity of analyzing transcript regulation resulting …
are not usually studied because of the complexity of analyzing transcript regulation resulting …
Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia
GH Kang, S Lee, HJ Lee… - The Journal of Pathology …, 2004 - Wiley Online Library
To date, several reports have been published about CpG island methylation of various
genes in prostate cancer. However, most of these studies have focused on cancer tissue …
genes in prostate cancer. However, most of these studies have focused on cancer tissue …
CpG island hypermethylation in cell‐free serum DNA identifies patients with localized prostate cancer
J Ellinger, K Haan, LC Heukamp, P Kahl… - The …, 2008 - Wiley Online Library
BACKGROUND One of the earliest and most common epigenetic events in prostate
carcinogenesis is DNA CpG island (CGI) hypermethylation. Our aim was to analyze the …
carcinogenesis is DNA CpG island (CGI) hypermethylation. Our aim was to analyze the …
Epigenetic changes in prostate cancer: implication for diagnosis and treatment
Prostate cancer is the most common noncutaneous malignancy and the second leading
cause of cancer death among men in the United States. DNA methylation and histone …
cause of cancer death among men in the United States. DNA methylation and histone …
Genome-wide methylation analysis identifies involvement of TNF-α mediated cancer pathways in prostate cancer
SJ Kim, WK Kelly, A Fu, K Haines, A Hoffman, T Zheng… - Cancer letters, 2011 - Elsevier
Altered signaling pathways resulting from aberrant changes in epigenetic parameters may
play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by …
play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by …
[HTML][HTML] Dynamic patterns of DNA methylation in the normal prostate epithelial differentiation program are targets of aberrant methylation in prostate cancer
Understanding the epigenetic control of normal differentiation programs might yield principal
information about critical regulatory states that are disturbed in cancer. We utilized the …
information about critical regulatory states that are disturbed in cancer. We utilized the …
In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer
TM Murphy, L Sullivan, C Lane, L O'Connor… - The …, 2011 - Wiley Online Library
BACKGROUND Aberrant DNA methylation has been implicated as a key survival
mechanism in cancer, whereby promoter hypermethylation silences genes essential for …
mechanism in cancer, whereby promoter hypermethylation silences genes essential for …