Background: The role of global DNA methylation in prostate cancer (PCa) remains largely
unknown. Our aim was to summarize evidence on the role of global DNA hypomethylation in …

In many cases, silencing of gene expression by CpG methylation is causally involved in
carcinogenesis. Furthermore, cancer-specific CpG methylation may serve as a tumor …

Background Current diagnostic tools for prostate cancer lack specificity and sensitivity for
detecting very early lesions. DNA methylation is a stable genomic modification that is …

Epigenetic changes are potentially important for the ontogeny and progression of tumors but
are not usually studied because of the complexity of analyzing transcript regulation resulting …

To date, several reports have been published about CpG island methylation of various
genes in prostate cancer. However, most of these studies have focused on cancer tissue …

BACKGROUND One of the earliest and most common epigenetic events in prostate
carcinogenesis is DNA CpG island (CGI) hypermethylation. Our aim was to analyze the …

Prostate cancer is the most common noncutaneous malignancy and the second leading
cause of cancer death among men in the United States. DNA methylation and histone …

Altered signaling pathways resulting from aberrant changes in epigenetic parameters may
play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by …

Understanding the epigenetic control of normal differentiation programs might yield principal
information about critical regulatory states that are disturbed in cancer. We utilized the …

BACKGROUND Aberrant DNA methylation has been implicated as a key survival
mechanism in cancer, whereby promoter hypermethylation silences genes essential for …