Background Prostate cancer (PCa) is the most prevalent type of male genitourinary tumor,
remains the second leading cause of deaths due to cancer in the United States in men. The …

DNA methylation of promoter regions is a common event in prostate cancer, one of the most
common cancers in men worldwide. Because prior reports demonstrating that DNA …

Current diagnostic and prognostic tools for prostate cancer (PC) are suboptimal, leading to
overdiagnosis and overtreatment. Aberrant promoter hypermethylation of specific genes has …

Prostate cancer is a highly prevalent malignancy, which is clinically silent but curable while
organ-confined. Because available screening methods show poor sensitivity and specificity …

During the last three decades, multiple studies have established that the DNA methylation
landscape of cancer cells is severely disrupted, including hypermethylation of CpG islands …

Altered DNA methylation in cancer cells is characterized by focal CpG island
hypermethylation and diffuse genomic hypomethylation. Both types of aberrant methylation …

Background We used a genome‐wide discovery approach to identify methylation markers
associated with metastasis in men with localized prostate cancer (PCa), as better …

Purpose: The aim of this study was to investigate the promoter hypermethylation as
diagnostic markers to detect malignant prostate cells and as prognostic markers to predict …

In prostate carcinoma (PCa) increased DNA methylation ('hypermethylation') occurs at
specific genes such as GSTP1. Nevertheless, overall methylation can be decreased …