Circadian clocks coordinate physiological, behavioral, and biochemical events with
predictable daily environmental changes by a self-sustained transcriptional feedback loop …

Background AMP protein kinase (AMPK) plays an important role in food intake and energy
metabolism, which are synchronized to the light-dark cycle. In vitro, AMPK affects the …

Circadian clocks coordinate behavior and physiology with daily environmental cycles and
thereby optimize the timing of metabolic processes such as glucose production and insulin …

Circadian clocks regulate behavioral, physiological and biochemical processes in a
day/night cycle. Circadian oscillators have an essential role in the coordination of …

Circadian clocks in mammals are built on a negative feedback loop in which the
heterodimeric transcription factor circadian locomotor output cycles kaput (CLOCK)-brain …

Circadian locomotor output cycles kaput (CLOCK) is a transcription factor that activates
transcription of clock-controlled genes by heterodimerizing with BMAL1 and binding to E …

Almost all organisms ranging from single cell bacteria to humans exhibit a variety of
behavioral, physiological, and biochemical rhythms. In mammals, circadian rhythms control …

Circadian rhythms are approximate 24-h behavioral and physiological cycles that function to
prepare an organism for daily environmental changes. The basic clock mechanism is a …

Circadian clocks are fundamental physiological regulators of energy homeostasis, but direct
transcriptional targets of the muscle clock machinery are unknown. To understand how the …

The circadian clock network is an evolutionarily conserved mechanism that imparts temporal
regulation to diverse biological processes. Brain and muscle Arnt-like 1 (Bmal1), an …