Deconvoluting lipid nanoparticle structure for messenger RNA delivery

Y Eygeris, S Patel, A Jozic, G Sahay - Nano letters, 2020 - ACS Publications
Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …

Chemistry of lipid nanoparticles for RNA delivery

Y Eygeris, M Gupta, J Kim, G Sahay - Accounts of chemical …, 2021 - ACS Publications
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …

Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)

E Álvarez-Benedicto, L Farbiak, MM Ramírez… - Biomaterials …, 2022 - pubs.rsc.org
Lipid nanoparticles (LNPs) have been established as an essential platform for nucleic acid
delivery. Efforts have led to the development of vaccines that protect against SARS-CoV-2 …

Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery

L Cui, S Pereira, S Sonzini, S van Pelt, SM Romanelli… - Nanoscale, 2022 - pubs.rsc.org
mRNA lipid nanoparticles (LNPs) are at the forefront of nucleic acid intracellular delivery, as
exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 …

Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement

R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …

Payload distribution and capacity of mRNA lipid nanoparticles

S Li, Y Hu, A Li, J Lin, K Hsieh, Z Schneiderman… - Nature …, 2022 - nature.com
Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and
therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs …

Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates

Y Suzuki, T Miyazaki, H Muto, K Kubara, Y Mukai… - … Therapy-Nucleic Acids, 2022 - cell.com
mRNA and lipid nanoparticles have emerged as powerful systems for the preparation of
vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection …

Mechanistic studies of an automated lipid nanoparticle reveal critical pharmaceutical properties associated with enhanced mRNA functional delivery in vitro and in …

L Cui, MR Hunter, S Sonzini, S Pereira, SM Romanelli… - Small, 2022 - Wiley Online Library
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …

Leveraging biological buffers for efficient messenger RNA delivery via lipid nanoparticles

MI Henderson, Y Eygeris, A Jozic… - Molecular …, 2022 - ACS Publications
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) have launched to the
forefront of nonviral delivery systems with their realized potential during the COVID-19 …