Deconvoluting lipid nanoparticle structure for messenger RNA delivery
Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …
Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)
E Álvarez-Benedicto, L Farbiak, MM Ramírez… - Biomaterials …, 2022 - pubs.rsc.org
Lipid nanoparticles (LNPs) have been established as an essential platform for nucleic acid
delivery. Efforts have led to the development of vaccines that protect against SARS-CoV-2 …
delivery. Efforts have led to the development of vaccines that protect against SARS-CoV-2 …
Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery
L Cui, S Pereira, S Sonzini, S van Pelt, SM Romanelli… - Nanoscale, 2022 - pubs.rsc.org
mRNA lipid nanoparticles (LNPs) are at the forefront of nucleic acid intracellular delivery, as
exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 …
exemplified by the recent emergency approval of two mRNA LNP-based COVID-19 …
Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement
R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
Payload distribution and capacity of mRNA lipid nanoparticles
Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and
therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs …
therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs …
Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates
Y Suzuki, T Miyazaki, H Muto, K Kubara, Y Mukai… - … Therapy-Nucleic Acids, 2022 - cell.com
mRNA and lipid nanoparticles have emerged as powerful systems for the preparation of
vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection …
vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection …
Mechanistic studies of an automated lipid nanoparticle reveal critical pharmaceutical properties associated with enhanced mRNA functional delivery in vitro and in …
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
Leveraging biological buffers for efficient messenger RNA delivery via lipid nanoparticles
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) have launched to the
forefront of nonviral delivery systems with their realized potential during the COVID-19 …
forefront of nonviral delivery systems with their realized potential during the COVID-19 …
相关搜索
- rna delivery lipid nanoparticles
- cells in the liver lipid nanoparticles
- gene therapy lipid nanoparticles
- rna therapeutics cells in the liver
- phospholipid chemistry lipid nanoparticle
- targeted delivery cells in the liver
- rna therapeutics targeted delivery
- biological buffers lipid nanoparticles
- mrna delivery lipid nanoparticles
- rna therapeutics lipid nanoparticles
- targeted delivery lipid nanoparticles