The reversal of digoxin effects by digoxin antibody (Ab) may be mediated by at least two
mechanisms. First, the Ab may simply decrease the concentration of free digoxin in the …

1. The actions of externally and internally applied digoxin in heart ventricular muscle have
been compared. 2. External application of digoxin (5 x 10 (‐8)‐‐10 (‐7) M) had an inotropic …

The effects of digoxin on electrophysiologic properties were evaluated in isolated perfused
cardiac tissue. In canine Purkinje fiber (PF)-ventricular muscle (VM) preparations, control …

Guinea-pig and rat hearts were perfused via the aorta at constant flow with 10-7 M digoxin-
H3 for periods up to 64 min. The temperature was 28° C. The hearts were then perfused for …

Pretreatment of guinea-pigs with digoxin-specific Fab (fragment antigen binding) fragments
reduced the cardiotoxicity of intravenously infused digoxin (the lethal doses in Fab-treated …

Specific antibodies to digoxin were isolated from antisera of sheep immunized with a digoxin-
human serum albumin conjugate. The antibody was purified by adsorption to an …

Thirty-four dogs were given tritium-labeled digoxin intravenously. Serum and tissue
concentrations and half-times were determined. As demonstrated previously in human …

Tritiated (12α‐3H) digoxin (0· 05 mg/kg body weight) was administered intravenously to
conscious dogs with circulatory volume overload induced by previous creation of aorto …

The extent and time course of the reversal of digoxin-induced inotropy by digoxin-specific
antibodies and their Fab fragments were studied in seven conscious dogs instrumented with …

In guinea‐pigs intravenously infused with digoxin, prior immunization using a digoxin‐
human serum albumin conjugate increased by 3‐and 2.4‐fold, respectively, the digoxin …