Circular RNAs: emerging cancer biomarkers and targets

Y Zhang, W Liang, P Zhang, J Chen, H Qian… - Journal of Experimental …, 2017 - Springer
CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are
abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity …

Molecular roles and function of circular RNAs in eukaryotic cells

LM Holdt, A Kohlmaier, D Teupser - Cellular and Molecular Life Sciences, 2018 - Springer
Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …

CircRNAs: role in human diseases and potential use as biomarkers

L Verduci, E Tarcitano, S Strano, Y Yarden… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …

Tumor‐suppressive circular RNAs: mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

Z Li, Y Ruan, H Zhang, Y Shen, T Li, B Xiao - Cancer science, 2019 - Wiley Online Library
Circular RNAs (circRNAs) have a covalently closed circular conformation and are
structurally stable. Those circRNAs with tumor‐suppressive properties play an important role …

Insights into circular RNA biology

KK Ebbesen, TB Hansen, J Kjems - RNA biology, 2017 - Taylor & Francis
Circular RNAs (circRNAs) are a novel class of non-coding RNA characterized by a
covalently closed-loop structure generated through a special type of alternative splicing …

Exploring the regulatory role of circular RNAs in neurodegenerative disorders

E D'Ambra, D Capauto, M Morlando - International journal of molecular …, 2019 - mdpi.com
Circular RNAs (circRNAs) are a distinctive class of regulatory non-coding RNAs
characterised by the presence of covalently closed ends. They are evolutionary conserved …

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

M Su, Y Xiao, J Ma, Y Tang, B Tian, Y Zhang, X Li… - Molecular cancer, 2019 - Springer
Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability.
CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location-and …

Circular RNAs in cancer: biogenesis, function, and clinical significance

J Li, D Sun, W Pu, J Wang, Y Peng - Trends in cancer, 2020 - cell.com
Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-
specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop …

Circular RNAs in the tumour microenvironment

Z Ma, Y Shuai, X Gao, X Wen, J Ji - Molecular Cancer, 2020 - Springer
Abstract Background Circular RNAs (circRNAs) are a new class of endogenous non-coding
RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted …

Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …