Importance Psychiatric diagnoses are currently distinguished based on sets of specific
symptoms. However, genetic and clinical analyses find similarities across a wide variety of …

Importance Alterations in multiple neuroimaging phenotypes have been reported in
psychotic disorders. However, neuroimaging measures can be influenced by factors that are …

Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …

Background Data-driven approaches can capture behavioral and biological variation
currently unaccounted for by contemporary diagnostic categories, thereby enhancing the …

The profile of brain structural abnormalities in schizophrenia is still not fully understood,
despite decades of research using brain scans. To validate a prospective meta-analysis …

The opportunity for neuroscience-based approaches to impact clinical psychiatry has never
been greater, yet biological measures have had almost no impact on psychiatric practice …

Despite an increasing focus on transdiagnostic approaches to mental health, it remains
unclear whether different diagnostic categories share a common neuronatomical basis. The …

It is increasingly recognized that multiple psychiatric conditions are underpinned by shared
neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural …

OBJECTIVE: Poor executive functioning is a core deficit in schizophrenia and has been
linked to frontal lobe alterations. We aimed to identify (1) prefrontal cerebral areas in which …

Objective Diagnoses using imaging-based measures alone offer the hope of improving the
accuracy of clinical diagnosis, thereby reducing the costs associated with incorrect …