Serous cells are the predominant site of cystic fibrosis transmembrane conductance
regulator expression in the airways, and they make a significant contribution to the volume …

The Calu-3 cell line is being investigated as a model for human submucosal gland serous
cells. In a previous investigation of basal short-circuit current (I sc) in Calu-3 cells, high …

Human airway serous cells secrete antibiotic-rich fluid, but, in cystic fibrosis (CF), Cl−-
dependent fluid secretion is impaired by defects in CF transmembrane conductance …

Adenosine 3', 5'-cyclic monophosphate stimulates chloride (Cl-) secretion across airway
epithelia. To determine whether cAMP also stimulates HCO3-secretion, we studied cultured …

Previous studies demonstrated that ACh-induced liquid secretion by porcine bronchi is
driven by active Cl− and H CO 3− secretion. The present study was undertaken to determine …

Chloride secretion across cystic fibrosis (CF) airway epithelia is effectively regulated by
pathways associated with intracellular Ca2+ metabolism, but not by mechanisms dependent …

We investigated the effect of homozygous genetic disruption of the murine cystic fibrosis
transmembrane regulator (CFTR) gene on regulation of the rates of Na+ absorption and Cl …

Cystic fibrosis (CF) airway epithelia express a defect in adenosine 3', 5'-cyclic
monophosphate (cAMP)-dependent regulation of apical membrane Cl-channels. Recent …

Using whole cell patch-clamp and perforated patch recording techniques on human cystic
fibrosis (CF) and non-CF airway epithelial cells, we sought to determine whether a single Cl …

Human airway epithelia express Ca 2+-activated Cl− channels (CaCC) that are activated by
extracellular nucleotides (ATP and UTP). CaCC is preserved and seems to be up-regulated …