The pathology of Parkinson's disease (PD) is characterized by α-synuclein aggregation,
microglia-mediated neuroinflammation, and dopaminergic neurodegeneration in the …

Background Parkinson's disease (PD) is characterized by the loss of nigral dopaminergic
neurons leading to impaired striatal dopamine signaling, α-synuclein-(α-syn-) rich …

Parkinson's disease (PD) is the second most common neurodegenerative disease, with two
main pathological features: misfolded α-synuclein protein accumulation and …

According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of
dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the
loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine …

Background Parkinson's disease (PD) is characterized by a progressive degeneration of
dopaminergic neurons, which leads to irreversible loss of peripheral motor functions. Death …

Chronic sterile inflammation and persistent immune activation is a prominent pathological
feature of Parkinson's disease (PD). Inflammasomes are multi-protein intracellular signaling …

Chronic inflammation might correlate with the formation of α-synuclein oligomers,
subsequently leading to dopaminergic (DA) neuronal death in Parkinson's disease (PD). As …

Parkinson's disease (PD) is mediated, in part, by intraneuronal accumulation of α-synuclein
aggregates andsubsequent death of dopamine (DA) neurons in the substantia nigra pars …