Skeletal elements are formed either by replacing a preformed cartilagenous matrix template
in a process called endochondral ossification or directly from mesenchyme by a process …

The type X collagen gene, COL10A1, is specifically expressed by hypertrophic chondrocytes
during endochondral ossification. Endochondral ossification is a well-coordinated process …

We have generated transgenic mice harboring the deletion of exon 48 in the mouse α1 (II)
procollagen gene (Col2a1). This was the first dominant negative mutation identified in the …

The majority of human skeleton develops through the endochondral pathway, in which
cartilage-forming chondrocytes proliferate and enlarge into hypertrophic chondrocytes that …

Endochondral ossification is the process by which the embryonic cartilaginous model of
most bones contributes to longitudinal growth and is gradually replaced by bone. During …

One of the crucial steps in endochondral bone formation is the replacement of a cartilage
matrix produced by chondrocytes with bone trabeculae made by osteoblasts. However, the …

The skeleton is composed of bone and cartilage. These tissues are made of an exquisite
assembly of functionally distinct cell populations and are required to support the structural …

Long bone development depends on endochondral bone formation, a complex process
requiring exquisite balance between hypertrophic cartilage (HC) formation and its …

The concern of chondrocyte-osteoblast transition in skeleton development has continued for
more than one century. Even though many morphological and in vitro data clearly indicated …

Abstract Background/Objective As one of the branched chains of Type IX collagen (Col9),
Collagen IX alpha2 (Col9a2) has been reported to be associated with several orthopedic …