Chemical, enzymatic and biological synthesis of hyaluronic acids

J Li, M Qiao, Y Ji, L Lin, X Zhang, RJ Linhardt - International journal of …, 2020 - Elsevier
Hyaluronic acid (HA) is a major glycosaminoglycan, a family of structurally complex, linear,
anionic hetero-co-polysaccharides. HA is important in various anatomical structures …

Bacterial hyaluronic acid production through an alternative extraction method and its characterization

G Güngör, S Gedikli, Y Toptaş… - Journal of Chemical …, 2019 - Wiley Online Library
BACKGROUND In this study, hyaluronic acid (HA) was produced using Streptococcus equi
ssp. equi via an optimized Central Composite Design process, with purification by an …

[HTML][HTML] Efficient production of high-molecular-weight hyaluronic acid with a two-stage fermentation

J Liu, Y Wang, Z Li, Y Ren, Y Zhao, G Zhao - RSC advances, 2018 - pubs.rsc.org
In this paper, the production pattern of hyaluronic acid (HA) was revealed: the chain growth
of HA mainly occurred in the first half of fermentation while the product accumulated …

[HTML][HTML] Microbial hyaluronic acid production: a review

M Serra, A Casas, D Toubarro, AN Barros, JA Teixeira - Molecules, 2023 - mdpi.com
Microbial production of hyaluronic acid (HA) is an area of research that has been gaining
attention in recent years due to the increasing demand for this biopolymer for several …

[HTML][HTML] Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms

JD de Oliveira, LS Carvalho, AMV Gomes… - Microbial cell …, 2016 - Springer
Hyaluronic acid, or HA, is a rigid and linear biopolymer belonging to the class of the
glycosaminoglycans, and composed of repeating units of the monosaccharides glucuronic …

Production methods for hyaluronan

CG Boeriu, J Springer, FK Kooy… - International journal …, 2013 - Wiley Online Library
Hyaluronan is a polysaccharide with multiple functions in the human body being involved in
creating flexible and protective layers in tissues and in many signalling pathways during …

Purification and biocompatibility of fermented hyaluronic acid for its applications to biomaterials

S Choi, W Choi, S Kim, SY Lee, I Noh… - Biomaterials …, 2014 - spj.science.org
Background Hyaluronic acid (HA) is of importance due to its diverse applications in
pharmaceuticals and medical devices such as dermal filler, adhesion barriers, carrier for …

[HTML][HTML] Hyaluronan as a prominent biomolecule with numerous applications in medicine

K Valachová, L Šoltés - International journal of molecular sciences, 2021 - mdpi.com
Hyaluronan (HA) is a natural glycosaminoglycan present in many tissues of all vertebrates.
HA has various biological functions, which are dependent on its molar mass. High-molar …

[HTML][HTML] Prospective bacterial and fungal sources of hyaluronic acid: A review

EV Shikina, RA Kovalevsky, AI Shirkovskaya… - Computational and …, 2022 - Elsevier
The unique biological and rheological properties make hyaluronic acid a sought-after
material for medicine and cosmetology. Due to very high purity requirements for hyaluronic …

High‐titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum

F Cheng, Q Gong, H Yu… - Biotechnology …, 2016 - Wiley Online Library
Hyaluronic acid (HA) plays important roles in human tissue system, thus it is highly desirable
for various applications, such as in medical, clinic and cosmetic fields. The wild microbial …