Hyaluronic acid production and molecular weight improvement by redirection of carbon flux towards its biosynthesis pathway

MV Shah, SS Badle, KB Ramachandran - Biochemical engineering journal, 2013 - Elsevier
Hyaluronic acid (HA) production in Streptococcus zooepidemicus competes for the carbon
source along with biomass formation, lactate formation (via glycolysis) and pentose …

Hyaluronic acid: redefining its role

G Abatangelo, V Vindigni, G Avruscio, L Pandis, P Brun - Cells, 2020 - mdpi.com
The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has
promoted new research impetus for biologists and, the clinical interest in several fields of …

Hyaluronan: metabolism and function

T Kobayashi, T Chanmee, N Itano - Biomolecules, 2020 - mdpi.com
As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential
roles in the organization of tissue architecture and the regulation of cellular functions, such …

Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications

G Kogan, L Šoltés, R Stern, P Gemeiner - Biotechnology letters, 2007 - Springer
Hyaluronic acid (hyaluronan, HA) is a linear polysaccharide formed from disaccharide units
containing N-acetyl-d-glucosamine and glucuronic acid. It has a high molecular mass …

Hyaluronic acid in the third millennium

A Fallacara, E Baldini, S Manfredini, S Vertuani - Polymers, 2018 - mdpi.com
Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of
research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide …

Hyaluronan: from biomimetic to industrial business strategy

E Murano, D Perin, R Khan… - Natural product …, 2011 - journals.sagepub.com
Hyaluronan (hyaluronic acid) is a naturally occurring polysaccharide of a linear repeating
disaccharide unit consisting of β-(1→ 4)-linked D-glucopyranuronic acid and β-(1→ 3) …

Influence of competing metabolic processes on the molecular weight of hyaluronic acid synthesized by Streptococcus zooepidemicus

S Jagannath, KB Ramachandran - Biochemical Engineering Journal, 2010 - Elsevier
Hyaluronic acid (HA) is a linear high molecular weight glycosaminoglycan polymer with its
molecular weight determining its physiological role, rheological properties and applications …

Preparation and applications of hyaluronic acid and its derivatives

G Huang, J Chen - International journal of biological macromolecules, 2019 - Elsevier
Hyaluronic acid (HA) is a mucopolysaccharide formed by the alternate connection of
glucuronic acid and N-acetylglucosamine as disaccharide units. In recent years, people …

Hyaluronic acid production enhancement via genetically modification and culture medium optimization in Lactobacillus acidophilus

FF Chahuki, S Aminzadeh, V Jafarian… - International journal of …, 2019 - Elsevier
Hyaluronic acid (HA) is a natural polymer with various molecular weights that specify
multiple biological roles. Traditionally, HA is obtained from animal waste and conventional …

Microbial hyaluronic acid production

BF Chong, LM Blank, R Mclaughlin… - Applied microbiology and …, 2005 - Springer
Abstracts Hyaluronic acid (HA) is a commercially valuable medical biopolymer increasingly
produced through microbial fermentation. Viscosity limits product yield and the focus of …