Hyaluronic acid or hyaluronan (HA) was the first isolated from bovine vitreous humor by
Meyer and Palmer [1] in 1934. It was named because of its transparent appearance in water …

The essential pathophysiological roles of hyaluronic acid (HA) strongly depend on HA
binding and HA size. Here we deployed the atomic vision of molecular dynamics (MD) …

Since hyaluronate (HA) was firstly isolated from the vitreous of bovine eyes in 1934, HA has
been widely investigated for various biomedical applications. As a naturally-occurring …

Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and
contributes to cell proliferation and migration. It is used as a stimulating agent for collagen …

Burns, mechanical injuries, skin defects, poor wound healing and scars caused by chronic
diseases are serious clinical issues that affect millions of people around the world …

It was probably the French chemist Portes, who first reported in 1880 that the mucin in the
vitreous body, which he named hyalomucine, behaved differently from other mucoids in …

The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing
hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic …

It has long been found that hyaluronidases exist in a variety of organisms, playing their roles
in various biological processes including infection, envenomation and metabolic regulation …

Microbial hyaluronic acid (HA) production has been preferred rather than extraction from
animal tissue for medical and cosmetic applications. In this context, to obtain an …

The mechanism of hyaluronan biosynthesis in vertebrates had been proposed to occur at
the reducing end of growing chains. This mechanism was questioned because a …