Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with~ 780,000 …

DB Rosoff, TK Clarke, MJ Adams, AM McIntosh… - Molecular …, 2021 - nature.com
Observational studies suggest that lower educational attainment (EA) may be associated
with risky alcohol use behaviors; however, these findings may be biased by confounding …

Educational attainment and drinking behaviors: Mendelian randomization study in UK Biobank

T Zhou, D Sun, X Li, H Ma, Y Heianza, L Qi - Molecular psychiatry, 2021 - nature.com
Educational attainment has been associated with drinking behaviors in observation studies.
We performed Mendelian randomization analysis to determine whether educational …

Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review

JL Treur, MR Munafò, E Logtenberg… - Psychological …, 2021 - cambridge.org
BackgroundPoor mental health has consistently been associated with substance use
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …

Educational differences in alcohol consumption and heavy drinking: An age-period-cohort perspective

CK Lui, WC Kerr, N Mulia, Y Ye - Drug and alcohol dependence, 2018 - Elsevier
Background Low socioeconomic status (SES) has been associated with lower alcohol
consumption, but also with heavier drinking. To explain this contradictory relationship, we …

Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population‐based cohort

TK Clarke, AH Smith, J Gelernter, HR Kranzler… - Addiction …, 2016 - Wiley Online Library
Alcohol dependence is frequently co‐morbid with cognitive impairment. The relationship
between these traits is complex as cognitive dysfunction may arise as a consequence of …

Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

AT Marees, DJA Smit, JS Ong, S MacGregor… - Psychological …, 2020 - cambridge.org
Background. Frequency and quantity of alcohol consumption are metrics commonly used to
measure alcohol consumption behaviors. Epidemiological studies indicate that these …

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

E Jorgenson, KK Thai, TJ Hoffmann, LC Sakoda… - Molecular …, 2017 - nature.com
Alcohol consumption is a complex trait determined by both genetic and environmental
factors, and is correlated with the risk of alcohol use disorders. Although a small number of …

Investigating causality in associations between education and smoking: a two-sample Mendelian randomization study

SH Gage, J Bowden, G Davey Smith… - International journal of …, 2018 - academic.oup.com
Background Lower educational attainment is associated with increased rates of smoking,
but ascertaining causality is challenging. We used two-sample Mendelian randomization …

Genome-wide association study of maximum habitual alcohol intake in> 140,000 US European and African American veterans yields novel risk loci

J Gelernter, N Sun, R Polimanti, RH Pietrzak… - Biological …, 2019 - Elsevier
Background Habitual alcohol use can be an indicator of alcohol dependence, which is
associated with a wide range of serious health problems. Methods We completed a genome …

Genome-wide association study of alcohol dependence

J Treutlein, S Cichon, M Ridinger… - Archives of general …, 2009 - jamanetwork.com
Context Alcohol dependence is a serious and common public health problem. It is well
established that genetic factors play a major role in the development of this disorder …