[HTML][HTML] Sex differences, estrogen metabolism and signaling in the development of pulmonary arterial hypertension

Y Sun, S Sangam, Q Guo, J Wang, H Tang… - Frontiers in …, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a complex and devastating disease with a poor
long-term prognosis. While women are at increased risk for developing PAH, they exhibit …

Higher estradiol and lower dehydroepiandrosterone-sulfate levels are associated with pulmonary arterial hypertension in men

CE Ventetuolo, GL Baird, RG Barr… - American journal of …, 2016 - atsjournals.org
Rationale: Recent studies have focused on the role of female sex and estradiol (E2) in
pulmonary arterial hypertension (PAH), but it is not known whether sex hormones are risk …

Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects

X Chen, ED Austin, M Talati, JP Fessel… - European …, 2017 - Eur Respiratory Soc
Increased oestrogen is a strong epidemiological risk factor for development of pulmonary
arterial hypertension (PAH) in patients, associated with metabolic defects. In addition …

Sex differences in pulmonary hypertension: are we cleaning up the mess?

T Lahm - European Respiratory Journal, 2016 - Eur Respiratory Soc
When I was looking for a research project to pursue as a fellow in 2006, I became interested
in sex differences in pulmonary arterial hypertension (PAH). When I proposed the idea of …

Estrogen paradox in pulmonary hypertension: current controversies and future perspectives

S Umar, M Rabinovitch, M Eghbali - American journal of respiratory …, 2012 - atsjournals.org
Although the incidence of pulmonary hypertension is higher in female patients, numerous
experimental studies have demonstrated better outcome in female animals, exacerbation of …

Estrogen Receptor-α Exerts Endothelium-Protective Effects and Attenuates Pulmonary Hypertension

AL Frump, B Yakubov, A Walts, A Fisher… - American Journal of …, 2023 - atsjournals.org
Even though pulmonary arterial hypertension (PAH) is more prevalent in women, women
with PAH exhibit better right ventricular (RV) function, more favorable RV treatment …

The estrogen puzzle in pulmonary arterial hypertension

R Paulin, ED Michelakis - Circulation, 2012 - Am Heart Assoc
The biology of pulmonary arterial hypertension (PAH) is full of mysteries, and one of its
longer-standing ones has also intrigued and inspired both scientists and artists throughout …

Gender, sex hormones and pulmonary hypertension

ED Austin, T Lahm, J West, SP Tofovic… - Pulmonary …, 2013 - journals.sagepub.com
Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater
susceptibility to disease among females, although females with PAH appear to live longer …

Gender, sex hormones, and pulmonary arterial hypertension

ED Austin - Advances in Pulmonary Hypertension, 2011 - meridian.allenpress.com
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary
vascular remodeling of the distal pulmonary vasculature, ultimately leading to destruction …

[HTML][HTML] Making sense of the estrogen paradox in pulmonary arterial hypertension

VA de Jesus Perez - American journal of respiratory and critical …, 2011 - atsjournals.org
Idiopathic pulmonary arterial hypertension (IPAH) is a rare but devastating disease that is
characterized by progressive elevation of the pulmonary pressures and, if untreated, leads …