Newer insights into the pathobiological and pharmacological basis of the sex disparity in patients with pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) affects more women than men, although affected
females tend to survive longer than affected males. This sex disparity in PAH is postulated to …
females tend to survive longer than affected males. This sex disparity in PAH is postulated to …
Sex matters in pulmonary arterial hypertension
R Naeije, M D'Alto - European Respiratory Journal, 2014 - Eur Respiratory Soc
It has been known for a while that female sex is a risk factor for pulmonary arterial
hypertension (PAH), but that women with the condition survive better than men [ 1–3] …
hypertension (PAH), but that women with the condition survive better than men [ 1–3] …
Sex hormones and vascular protection in pulmonary arterial hypertension
HA Christou, RA Khalil - Journal of cardiovascular pharmacology, 2010 - journals.lww.com
Pulmonary arterial hypertension (PAH) is a serious disease and a major public health
problem with approximately 1000 new patients diagnosed every year in the United States. 1 …
problem with approximately 1000 new patients diagnosed every year in the United States. 1 …
17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor–mediated effects
T Lahm, M Albrecht, AJ Fisher, M Selej… - American journal of …, 2012 - atsjournals.org
Rationale: 17β-Estradiol (E2) attenuates hypoxic pulmonary vasoconstriction and hypoxic
pulmonary hypertension (HPH) through an unknown mechanism that may involve estrogen …
pulmonary hypertension (HPH) through an unknown mechanism that may involve estrogen …
Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females
Mutations in bone morphogenetic protein receptor type 2 (BMPR2) cause familial pulmonary
arterial hypertension (FPAH), but the penetrance is reduced and females are significantly …
arterial hypertension (FPAH), but the penetrance is reduced and females are significantly …
Pulmonary hypertension in women
ME Pugh, AR Hemnes - Expert review of cardiovascular therapy, 2010 - Taylor & Francis
Female predominance in pulmonary arterial hypertension (PAH) has been known for
several decades and recent interest in the effects of sex hormones on the development of …
several decades and recent interest in the effects of sex hormones on the development of …
[HTML][HTML] Exogenous estrogen preserves distal pulmonary arterial mechanics and prevents pulmonary hypertension in rats
JL Philip, DM Tabima, GD Wolf, AL Frump… - American Journal of …, 2020 - atsjournals.org
17b-estradiol (E2), the most abundant female sex steroid, has been implicated in the
development and progression of pulmonary arterial hypertension (PAH)(1, 2). Although …
development and progression of pulmonary arterial hypertension (PAH)(1, 2). Although …
Sex-dependent influence of endogenous estrogen in pulmonary hypertension
KM Mair, AF Wright, N Duggan… - American journal of …, 2014 - atsjournals.org
Rationale: The incidence of pulmonary arterial hypertension is greater in women,
suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in …
suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in …
Insights from the menstrual cycle in pulmonary arterial hypertension
Rationale: Sex hormones play a role in pulmonary arterial hypertension (PAH), but the
menstrual cycle has never been studied. Objectives: We conducted a prospective …
menstrual cycle has never been studied. Objectives: We conducted a prospective …
Impact of pituitary–gonadal axis hormones on pulmonary arterial hypertension in men
WH Wu, P Yuan, SJ Zhang, X Jiang, C Wu, Y Li… - …, 2018 - Am Heart Assoc
The association of sex hormone (estradiol, testosterone, and progesterone) with
cardiopulmonary disease has already attracted great attention, especially in pulmonary …
cardiopulmonary disease has already attracted great attention, especially in pulmonary …