Are women more at risk of false-positive primary aldosteronism screening and unnecessary suppression testing than men?

AH Ahmed, RD Gordon, PJ Taylor… - The Journal of …, 2011 - academic.oup.com
abstract Background: Because primary aldosteronism is not uncommon, specifically
treatable and in some cases curable, and carries higher risks for cardiovascular morbidity …

Can screening and confirmatory testing in the management of patients with primary aldosteronism be improved?

M Stowasser, A Ahmed, Z Guo, M Wolley… - Hormone and …, 2017 - thieme-connect.com
Widespread application of the plasma aldosterone/renin ratio (ARR) as a screening test has
led to the recognition that primary aldosteronism (PA) is the most common specifically …

Effects of female sex hormones and contraceptive pill on the diagnostic work-up for primary aldosteronism

F Pizzolo, R Raffaelli, A Memmo, L Chiecchi… - Journal of …, 2010 - journals.lww.com
Objectives Due to the widespread use of the aldosterone to renin ratio (ARR), primary
aldosteronism is currently recognized as a frequent cause of secondary hypertension. After …

The ovarian cycle as a factor of variability in the laboratory screening for primary aldosteronism in women

E Fommei, S Ghione, A Ripoli, S Maffei… - Journal of human …, 2009 - nature.com
Primary aldosteronism is increasingly investigated in hypertension being associated with an
elevated cardiovascular risk. Aldosterone has been reported to increase in the luteal phase …

Screening for primary aldosteronism in essential hypertension: diagnostic accuracy of the ratio of plasma aldosterone concentration to plasma renin activity

GL Schwartz, ST Turner - Clinical chemistry, 2005 - academic.oup.com
Background: The ratio of plasma aldosterone concentration to plasma renin activity (PRA) is
considered the screening test of choice for primary aldosteronism. Uncertainty exists …

Intra-individual variability of serum aldosterone and implications for primary aldosteronism screening

AAW Maciel, TC Freitas, GFC Fagundes… - The Journal of …, 2023 - academic.oup.com
Context Primary aldosteronism (PA) screening relies on an elevated aldosterone to renin
ratio with a minimum aldosterone level, which varies from 10 to 15 ng/dL (277-415.5 pmol/L) …

Should aldosterone suppression tests be conducted during a particular phase of the menstrual cycle, and, if so, which phase? Results of a preliminary study

AH Ahmed, RD Gordon, G Ward, M Wolley… - Clinical …, 2015 - Wiley Online Library
Background As renin and aldosterone levels vary during the menstrual cycle, and are critical
criteria for interpretation of aldosterone suppression tests to confirm or exclude primary …

Screening for primary aldosteronism: implications of an increased plasma aldosterone/renin ratio

GL Schwartz, AB Chapman, E Boerwinkle… - Clinical …, 2002 - academic.oup.com
Background: The value of the ratio of plasma aldosterone concentration (aldosterone) to
plasma renin activity (renin) to identify patients at risk for primary aldosteronism is …

Factors affecting the aldosterone/renin ratio

M Stowasser, AH Ahmed, E Pimenta… - Hormone and …, 2012 - thieme-connect.com
Although the aldosterone/renin ratio (ARR) is the most reliable screening test for primary
aldosteronism, false positives and negatives occur. Dietary salt restriction, concomitant …

Use of plasma aldosterone concentration-to-plasma renin activity ratio as a screening test for primary aldosteronism: a systematic review of the literature

VM Montori, WF Young - Endocrinology and Metabolism Clinics, 2002 - endo.theclinics.com
Objective. We conducted a systematic review of the literature to establish the test
characteristics (sensitivity, specificity, likelihood ratios at different cutoff values) of the …