Adenosine monophosphate-activated protein kinase abates hyperglycaemia-induced neuronal injury in experimental models of diabetic neuropathy: effects on …

VG Yerra, A Kumar - Molecular neurobiology, 2017 - Springer
Impaired adenosine monophosphate kinase (AMPK) signalling under hyperglycaemic
conditions is known to cause mitochondrial dysfunction in diabetic sensory neurons …

Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

Y Peng, J Liu, L Shi, Y Tang, D Gao… - Journal of …, 2016 - Wiley Online Library
Recent studies have demonstrated brain insulin signaling impairment and mitochondrial
dysfunction in diabetes. Hyperinsulinemia and hyperlipidemia arising from diabetes have …

Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic …

VG Yerra, AK Kalvala, B Sherkhane, A Areti… - Neuropharmacology, 2018 - Elsevier
Adenosine monophosphate-activated protein kinase (AMPK) has been studied for its myriad
metabolic and mitochondrial benefits in several chronic diseases. Recent studies have …

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral …

SK Roy Chowdhury, DR Smith, A Saleh, J Schapansky… - Brain, 2012 - academic.oup.com
Mitochondrial dysfunction occurs in sensory neurons and may contribute to distal
axonopathy in animal models of diabetic neuropathy. The adenosine monophosphate …

DW14006 as a direct AMPKα activator ameliorates diabetic peripheral neuropathy in mice

X Xu, W Wang, Z Wang, J Lv, X Xu, J Xu, J Yang… - Diabetes, 2020 - Am Diabetes Assoc
Diabetic peripheral neuropathy (DPN) is a long-term complication of diabetes with a
complicated pathogenesis. AMP-activated protein kinase (AMPK) senses oxidative stress …

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

SKR Chowdhury, DR Smith, P Fernyhough - Neurobiology of Disease, 2013 - Elsevier
Diabetic neuropathy is a neurological complication of diabetes that causes significant
morbidity and, because of the obesity-driven rise in incidence of type 2 diabetes, is …

Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events

P Fernyhough - Current diabetes reports, 2015 - Springer
Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous
system where mitochondrial dysfunction has been implicated as an etiological factor …

Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes

SKR Chowdhury, RT Dobrowsky, P Fernyhough - Mitochondrion, 2011 - Elsevier
Diabetic neuropathy is a major complication of diabetes that results in the progressive
deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed …

Hyperglycemia/hypoglycemia-induced mitochondrial dysfunction and cerebral ischemic damage in diabetics

AK Rehni, N Nautiyal, MA Perez-Pinzon… - Metabolic brain disease, 2015 - Springer
Enhancement of ischemic brain damage is one of the most serious complications of
diabetes. Studies from various in vivo and in vitro models of cerebral ischemia have led to …

Effects of mitochondrial dysfunction via AMPK/PGC-1 α signal pathway on pathogenic mechanism of diabetic peripheral neuropathy and the protective effects of …

Q Zhang, X Liang - Chinese Journal of Integrative Medicine, 2019 - Springer
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of
peripheral nervous system with high energy requirement. The adenosine monophosphate …