Adenosine monophosphate-activated protein kinase abates hyperglycaemia-induced neuronal injury in experimental models of diabetic neuropathy: effects on …
Impaired adenosine monophosphate kinase (AMPK) signalling under hyperglycaemic
conditions is known to cause mitochondrial dysfunction in diabetic sensory neurons …
conditions is known to cause mitochondrial dysfunction in diabetic sensory neurons …
Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons
Y Peng, J Liu, L Shi, Y Tang, D Gao… - Journal of …, 2016 - Wiley Online Library
Recent studies have demonstrated brain insulin signaling impairment and mitochondrial
dysfunction in diabetes. Hyperinsulinemia and hyperlipidemia arising from diabetes have …
dysfunction in diabetes. Hyperinsulinemia and hyperlipidemia arising from diabetes have …
Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic …
Adenosine monophosphate-activated protein kinase (AMPK) has been studied for its myriad
metabolic and mitochondrial benefits in several chronic diseases. Recent studies have …
metabolic and mitochondrial benefits in several chronic diseases. Recent studies have …
Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral …
Mitochondrial dysfunction occurs in sensory neurons and may contribute to distal
axonopathy in animal models of diabetic neuropathy. The adenosine monophosphate …
axonopathy in animal models of diabetic neuropathy. The adenosine monophosphate …
DW14006 as a direct AMPKα activator ameliorates diabetic peripheral neuropathy in mice
Diabetic peripheral neuropathy (DPN) is a long-term complication of diabetes with a
complicated pathogenesis. AMP-activated protein kinase (AMPK) senses oxidative stress …
complicated pathogenesis. AMP-activated protein kinase (AMPK) senses oxidative stress …
The role of aberrant mitochondrial bioenergetics in diabetic neuropathy
SKR Chowdhury, DR Smith, P Fernyhough - Neurobiology of Disease, 2013 - Elsevier
Diabetic neuropathy is a neurological complication of diabetes that causes significant
morbidity and, because of the obesity-driven rise in incidence of type 2 diabetes, is …
morbidity and, because of the obesity-driven rise in incidence of type 2 diabetes, is …
Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events
P Fernyhough - Current diabetes reports, 2015 - Springer
Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous
system where mitochondrial dysfunction has been implicated as an etiological factor …
system where mitochondrial dysfunction has been implicated as an etiological factor …
Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes
Diabetic neuropathy is a major complication of diabetes that results in the progressive
deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed …
deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed …
Hyperglycemia/hypoglycemia-induced mitochondrial dysfunction and cerebral ischemic damage in diabetics
AK Rehni, N Nautiyal, MA Perez-Pinzon… - Metabolic brain disease, 2015 - Springer
Enhancement of ischemic brain damage is one of the most serious complications of
diabetes. Studies from various in vivo and in vitro models of cerebral ischemia have led to …
diabetes. Studies from various in vivo and in vitro models of cerebral ischemia have led to …
Effects of mitochondrial dysfunction via AMPK/PGC-1 α signal pathway on pathogenic mechanism of diabetic peripheral neuropathy and the protective effects of …
Q Zhang, X Liang - Chinese Journal of Integrative Medicine, 2019 - Springer
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of
peripheral nervous system with high energy requirement. The adenosine monophosphate …
peripheral nervous system with high energy requirement. The adenosine monophosphate …
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