Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of
death in critically ill patients. It is the most common condition with high mortality in intensive …

Sepsis syndromes have been recognized since antiquity yet still pose significant challenges
to modern medicine. One of the biggest challenges lies in the heterogeneity of triggers and …

Sepsis and septic shock are a major public health concern and are still associated with high
rates of morbidity and mortality. Whilst there is growing understanding of different …

Intensive and critical care medicine has gone through unprecedented development over the
last few decades. According to recent surveys, we now treat severalfold more critically ill …

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Sepsis is the most important cause of morbidity and mortality in the intensive care unit (ICU),
but it lacks specific clinical manifestations. As a result, sensitive and specific indicators of …

Sepsis is a critical patient condition with high mortality rate caused by a complex and
inadequate host response to infection. Since early identification and start of antibiotic …

Sepsis is, in many patients, very difficult to recognise, especially early on and in the elderly
and those with multiple comorbidities. This difficulty leads to delayed treatment in some, and …

The last two to three years provided several “big steps” regarding our understanding and
management of sepsis. The increasing insight into pathomechanisms of post-infectious …

There is much enthusiasm and interest in sepsis biomarkers, particularly because sepsis is
a highly lethal condition, its diagnosis is challenging, and even simple treatment with …