Drug resistance among adolescents and young adults with virologic failure of first-line antiretroviral therapy and response to second-line treatment

V Kouamou, B Varyani, T Shamu… - AIDS research and …, 2020 - liebertpub.com
Barriers to sustainable virologic suppression (VS) of HIV-infected adolescents and young
adults include drug resistance mutations (DRMs) and limited treatment options, which may …

Pretreatment and acquired antiretroviral drug resistance among persons living with HIV in four African countries

TA Crowell, B Danboise, A Parikh… - Clinical Infectious …, 2021 - academic.oup.com
Background Emerging HIV drug resistance (HIVDR) could jeopardize the success of
standardized HIV management protocols in resource-limited settings. We characterized …

Virological response and resistance profiles after 18 to 30 months of first-or second-/third-line antiretroviral treatment: a cross-sectional evaluation in HIV type 1 …

C Charpentier, JC Gody, O Mbitikon… - AIDS research and …, 2012 - liebertpub.com
Abstract A total of 242 HIV-1-infected children were followed up at the Complexe Pédiatrique
of Bangui, Central African Republic, including 165 receiving antiretroviral treatment in first …

Pretreatment HIV drug resistance among adults initiating or re-initiating first-line antiretroviral therapy in Zimbabwe: fast-tracking the transition to dolutegravir-based …

V Kouamou, J Mavetera, J Manasa… - AIDS Research and …, 2021 - liebertpub.com
Pretreatment drug resistance (PDR) can compromise antiretroviral therapy (ART) efficacy
and undermine the WHO targets to end the AIDS epidemic as a public health threat by 2030 …

Pretreatment HIV drug resistance predicts accumulation of new mutations in ART‐naïve Ugandan children

S Soeria‐Atmadja, P Amuge, S Nanzigu… - Acta …, 2020 - Wiley Online Library
Aim To assess the prevalence of pretreatment drug resistance (PDR) and its association
with virologic outcomes after 24 weeks of antiretroviral therapy (ART), within an urban cohort …

Patterns of HIV-1 drug resistance after first-line antiretroviral therapy (ART) failure in 6 sub-Saharan African countries: implications for second-line ART strategies

RL Hamers, KCE Sigaloff, AM Wensing… - Clinical infectious …, 2012 - academic.oup.com
Background. Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the
benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug …

HIV drug resistance in persons initiating or reinitiating first‐line antiretroviral therapy in Paraguay: Results of a National Patient Survey

G Aguilar, HHM Truong, P Ovelar… - Journal of Medical …, 2022 - Wiley Online Library
Human immunodeficiency virus (HIV) drug resistance increases mortality and morbidity and
antiretroviral therapy (ART) costs. We describe Paraguay's first nationally representative …

[HTML][HTML] Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis

A Hauser, F Goldstein, ML Reichmuth… - Journal of clinical …, 2022 - Elsevier
Objective: To estimate the prevalence of NRTI and NNRTI drug resistance mutations in
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …

Pretreatment HIV drug resistance results in virological failure and accumulation of additional resistance mutations in Ugandan children

C Kityo, RS Boerma, KCE Sigaloff… - Journal of …, 2017 - academic.oup.com
Background Pretreatment HIV drug resistance (PDR) can impair virological response to
ART, jeopardizing effective treatment for children. Methods Children aged≤ 12 years …

Prevalence and correlates of pre-treatment HIV drug resistance among HIV-infected children in Ethiopia

BT Tadesse, O Tsai, A Chala, TE Chaka, T Eromo… - Viruses, 2019 - mdpi.com
Pediatric human immunodeficiency virus (HIV) care in resource-limited settings remains a
major challenge to achieving global HIV treatment and virologic suppression targets, in part …