Purpose: Investigate the metabolomic profile of synovial fluid from patients with and without
knee osteoarthritis (OA), in order to identify new metabolic markers for therapeutic targets …

Osteoarthritis (OA) is a leading cause of chronic joint pain in the older human population.
Diagnosis of OA at an earlier stage may enable the development of new treatments to one …

Background Metabolomics is the study of unique chemical imprints that represent specific
cellular processes in a cell, tissue, organ or organism. Synovial fluid in pathologic conditions …

Objective Inflammatory responses are associated with changes in tissue metabolism. Prior
studies find altered metabolomic profiles in both the synovial fluid (SF) and serum of …

Objectives Currently there are no reliable biomarkers in the synovial fluid available to
differentiate between septic and non-septic arthritis or to predict the prognosis of …

Objective The hip and knee joints differ biomechanically in terms of contact stresses, fluid
lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) …

Objectives To investigate potential pathogenic pathways in the synovial fluid of osteoarthritis
(OA) patients at different disease stages [early vs. late, determined based on the Kellgren …

Introduction Rheumatoid arthritis (RA) and osteoarthritis (OA) are clinicopathologically
different. Objectives We aimed to assess the feasibility of metabolomics in differentiating the …

To identify special metabolites in synovial fluid of osteoarthritis (OA) via a metabolomics
approach. Synovial fluid of 35 participants (25 OA patients and 10 controls) was detected by …

Objective Synovial fluid (SF) accumulates extensively in joints of individuals with rheumatoid
arthritis (RA), which reflects the pathological state of the synovium and disease activity. This …