HuR as a molecular target for cancer therapeutics and immune-related disorders

M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

Targeting the RNA-binding protein HuR in cancer

JM Finan, TL Sutton, DA Dixon, JR Brody - Cancer Research, 2023 - AACR
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …

The RNA-binding protein HuR in human cancer: A friend or foe?

X Wu, L Xu - Advanced drug delivery reviews, 2022 - Elsevier
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

The RNA binding protein HuR: a promising drug target for anticancer therapy

M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …

Targeting the multifaceted HuR protein, benefits and caveats

C Zucal, V D'Agostino, R Loffredo, B Mantelli… - Current drug …, 2015 - ingentaconnect.com
The RNA-binding protein (RBP) HuR is one of the most widely studied regulators of the
eukaryotic posttranscriptional gene expression and it plays a physiological role in mediating …

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …

HuR as therapeutic target in cancer: what the future holds

D Goutas, A Pergaris, C Giaginis… - Current Medicinal …, 2022 - ingentaconnect.com
ELAV-like protein 1 or HuR (human antigen R) is an RNA-binding protein that in humans is
encoded by the ELAVL1 gene, and one of its best functions is to stabilize mRNAs in order to …

Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts

X Wu, R Ramesh, J Wang, Y Zheng… - Journal of medicinal …, 2023 - ACS Publications
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …

Identification and validation of novel small molecule disruptors of HuR-mRNA interaction

X Wu, L Lan, DM Wilson, RT Marquez… - ACS chemical …, 2015 - ACS Publications
HuR, an RNA binding protein, binds to adenine-and uridine-rich elements (ARE) in the 3′-
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …

Posttranslational control of HuR function

I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …