Importance Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized
by formation of long chains of hemoglobin when deoxygenated within capillary beds …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Background Sickle cell disease (SCD) is a common, severe disorder that includes
congenital hemolytic anemias caused by inherited point mutations in the β-globin gene. 1 …

Sickle cell disease (SCD) is the name for a group of genetic blood disorders caused by
sickle hemoglobin (Hb S). The 2 key features of SCD are chronic hemolytic anemia and …

Sickle cell disease (SCD) is a single gene disorder causing a debilitating systemic
syndrome characterised by chronic anaemia, acute painful episodes, organ infarction and …

Sickle cell disease (SCD) is an umbrella term for a group of life‐long debilitating autosomal
recessive disorders that are caused by a single‐point mutation (Glu→ Val) that results in …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

Sickle cell disease (SCD) is a genetic blood disorder caused by abnormal hemoglobin that
damages and deforms red blood cells (RBCs). The abnormal red cells break down, causing …

Sickle Cell Anemia and Related Hemoglobinopathies Page 1 Sickle Cell Anemia and Related
Hemoglobinopathies Elliott P. Vichinsky, MD,* and Bertram H. Lubin, MDt SICKLE CELL …