l-(m-Trifluoromethylphenyl) piperazine, a serotonin agonist, lowered blood pressure in
spontaneously hypertensive rats (SHR) at doses of 2 to 10 mg/kg sc A structurally related …

LY53857 was a potent antagonist of vascular contraction to serotonin, which is mediated by
serotonergic (5-HT2) receptors, with a dissociation constant in vitro of 5.4 X 10 (-11) M …

The combination of fluoxetine (10 mg/kg) and L-5-hydroxytryptophan (5-HTP)(10 mg/kg)
significantly lowered blood pressure in spontaneously hypertensive rats and in rats made …

mCPP (meta-chlorophenylpiperazine) has agonist activity at some central serotonin
receptors and antagonist activity at peripheral vascular 5HT2 receptors, both effects that …

In vitro affinity for vascular 5HT2 and alpha receptors was determined for several
compounds (spiperone, ketanserin, mianserin, trazodone, mepiprazole, benzoctamine, m …

To investigate the role of the serotonergic nervous system in blood pressure regulation, 5μg
of 5-hydroxytryptamine (5-HT) was given icv before and after 1 μg of icv xylamidine or 200μg …

In pentobarbitone-or urethane-anaesthetized normotensive rats the triphasic pressure
response to serotonin (5-HT): a short-lasting depressor phase with an intense bradycardia, a …

The stimulation of central serotonin receptors leading to a decrease in blood pressure is well
documented, but the nature of these receptors is not well known. It was therefore decided to …

Noradrenaline and alpha-methylnoradrenaline applied to the area of the nucleus tractus
solitarii of the medulla oblongata decreased arterial blood pressure and heart rate of …

Abstract Serotonin (5-hydroxytryptamine; also called 5-HT) modifies cardiovascular activity
by central as well as peripheral sites of action. When 5-HT is injected within the central …