We report on molecular dynamics simulations of major histocompatibility complex (MHC)–
peptide complexes. Class I MHC molecules play an important role in cellular immunity by …

An automatic protein design procedure was used to compute amino acid sequences of
peptides likely to bind the HLA-A2 major histocompatibility complex (MHC) class I allele. The …

Possible conformation of major histocompatibility antigens was proposed on the basis of
homology between domains of major histocompatibility antigen polypeptide chains and …

The expressed gene products of the class I major histocompatibility complex (MHC) are now
recognized as key elements in the mechanism used by cytotoxic T-lymphocytes (CTLs) to …

Major histocompatibility complex (MHC) class II molecules bind to numerous peptides and
display these on the cell surface for T cell recognition. In a given immune response …

The structure of the peptide-binding specificity of major histocompatibility complex (MHC)
class I has been analyzed extensively in human and mouse. For fish, there are no …

We show that a rapidly executable computational procedure provides the basis for a
predictive understanding of antigenic peptide side chain specificity, for binding to class I …

The major histocompatibility complex-encoded class I molecule, a noncovalent dimer of a
polymorphic 45-kDa heavy chain and a nonpolymorphic 12-kDa beta 2-microglobulin (beta …

We have previously experimentally analyzed the structural requirements for interaction
between peptide antigens and mouse major histocompatibility complex (MHC) molecules of …

MHC class II molecules bind peptide antigens and present them to T cells. Recent evidence
suggests that peptide-MHC class II interaction is regulated by pH. Both peptide binding to …