Mutations in the X-linked aristaless-related homeobox gene (ARX) have been linked to
structural brain anomalies as well as multiple neurocognitive deficits. The generation of Arx …

ARX (the aristaless-related homeobox gene) is a transcription factor that participates in the
development of GABAergic and cholinergic neurons in the forebrain. Many ARX mutations …

Mutations in the aristaless-related homeobox (ARX) gene are associated with multiple
neurologic disorders in humans. Studies in mice indicate Arx plays a role in neuronal …

Mutations in the Aristaless-related homeobox (ARX) gene are found in a spectrum of
epilepsy and X-linked intellectual disability disorders. During development Arx is expressed …

X-linked Infantile Spasms Syndrome (ISSX) is a catastrophic epilepsy of early childhood with
intractable seizures, intellectual disability, and poor prognosis. A spectrum of mutations in …

Male embryonic mice with mutations in the X-linked aristaless-related homeobox gene (Arx)
developed with small brains due to suppressed proliferation and regional deficiencies in the …

Genetic investigations of X-linked mental retardation have demonstrated the implication of
ARX in a wide spectrum of disorders extending from phenotypes with severe neuronal …

Mental retardation and epilepsy often occur together. They are both heterogeneous
conditions with acquired and genetic causes. Where causes are primarily genetic, major …

Background Aristaless-related homeobox (ARX) is a paired-like homeodomain transcription
factor that functions primarily as a transcriptional repressor and has been implicated in …

Recent human genetics approaches identified the Aristaless-related homeobox (ARX) gene
as the causative gene in X-linked infantile spasms, Partington syndrome, and non …