[HTML][HTML] Lung deposition of inhaled tobramycin with eFlow rapid/LC Plus jet nebuliser in healthy and cystic fibrosis subjects
W Lenney, F Edenborough, P Kho, JM Kovarik - Journal of Cystic Fibrosis, 2011 - Elsevier
BACKGROUND: Reducing nebulisation times for tobramycin solution for inhalation in cystic
fibrosis (CF) may improve compliance. METHODS: In this single-dose, open-label, two-way …
fibrosis (CF) may improve compliance. METHODS: In this single-dose, open-label, two-way …
Efficacy and safety of aerosolized tobramycin in cystic fibrosis
VB Pai, MC Nahata - Pediatric pulmonology, 2001 - Wiley Online Library
Aerosolized tobramycin has been extensively used in cystic fibrosis (CF) patients in order to
directly deliver the antibiotic to the endobronchial site of infection, and decrease toxicity by …
directly deliver the antibiotic to the endobronchial site of infection, and decrease toxicity by …
Inhalation of tobramycin in cystic fibrosis: part 2: optimization of the tobramycin solution for a jet and an ultrasonic nebulizer
PPH Le Brun, AH De Boer, D Gjaltema… - International journal of …, 1999 - Elsevier
The inhalation of tobramycin is part of current cystic fibrosis (CF) therapy. Local therapy with
inhaled antibiotics has demonstrated improvements in pulmonary function. Current …
inhaled antibiotics has demonstrated improvements in pulmonary function. Current …
Inhalation of tobramycin using simulated cystic fibrosis patient profiles
A Haynes, D Geller, J Weers, B Ament… - Pediatric …, 2016 - Wiley Online Library
Summary Introduction TOBI® Podhaler™ is a capsule‐based drug‐device combination
(tobramycin inhalation powder [TIP] 28 mg capsules via unit‐dose dry powder T‐326 Inhaler …
(tobramycin inhalation powder [TIP] 28 mg capsules via unit‐dose dry powder T‐326 Inhaler …
Tobramycin inhalation powder manufactured by improved process in cystic fibrosis: the randomized EDIT trial
I Galeva, MW Konstan, M Higgins… - … medical research and …, 2013 - Taylor & Francis
Background: Tobramycin inhalation powder (TIP) was reported to be effective in two Phase
III studies in patients with cystic fibrosis (CF) chronically infected with Pseudomonas …
III studies in patients with cystic fibrosis (CF) chronically infected with Pseudomonas …
Pharmacokinetics and safety of tobramycin after once-daily administration in patients with cystic fibrosis
RD Bates, MC Nahata, JW Jones, K McCoy, G Young… - Chest, 1997 - Elsevier
Study objective Tobramycin is commonly used to treat respiratory tract infections in patients
with cystic fibrosis. We designed a study to determine the pharmacokinetics and safety of …
with cystic fibrosis. We designed a study to determine the pharmacokinetics and safety of …
Tobramycin inhalation powder for P. aeruginosa infection in cystic fibrosis: The EVOLVE trial
MW Konstan, DE Geller, P Minić… - Pediatric …, 2011 - Wiley Online Library
Tobramycin inhalation solution is used to treat chronic Pseudomonas aeruginosa lung
infection in cystic fibrosis (CF) patients. We evaluated the efficacy and safety of a novel, light …
infection in cystic fibrosis (CF) patients. We evaluated the efficacy and safety of a novel, light …
[HTML][HTML] Inhaled versus nebulised tobramycin: a real world comparison in adult cystic fibrosis (CF)
MJ Harrison, M McCarthy, C Fleming, C Hickey… - Journal of Cystic …, 2014 - Elsevier
Background There are no published data on real-life clinical experience comparing inhaled
antibiotic therapy via new rapid delivery systems with nebulised antibiotic therapy in CF …
antibiotic therapy via new rapid delivery systems with nebulised antibiotic therapy in CF …
Efficacy, Safety, and Local Pharmacokinetics of Highly Concentrated Nebulized Tobramycin in Patients with Cystic Fibrosis Colonized with Pseudomonas aeruginosa
G Lenoir, YG Antypkin, A Miano, P Moretti, M Zanda… - Pediatric Drugs, 2007 - Springer
Background and aim Progressive respiratory failure due to Pseudomonas aeruginosa
colonization is the most significant morbidity in patients with cystic fibrosis (CF). This trial …
colonization is the most significant morbidity in patients with cystic fibrosis (CF). This trial …
Inhalation of tobramycin in cystic fibrosis: part 1: the choice of a nebulizer
PPH Le Brun, AH De Boer, D Gjaltema… - International journal of …, 1999 - Elsevier
Forteen commercially available jet and ultrasonic nebulizers were investigated with the aim
to select the most suitable type of apparatus for the inhalation of a 10% tobramycin solution …
to select the most suitable type of apparatus for the inhalation of a 10% tobramycin solution …