[HTML][HTML] Overview of bile acid signaling in the cardiovascular system

R Zhang, WQ Ma, MJ Fu, J Li, CH Hu… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Bile acids (BAs) are classically known to play a vital role in the metabolism of lipids and in
absorption. It is now well established that BAs act as signaling molecules, activating different …

Physiological role of bile acids modified by the gut microbiome

Y Kiriyama, H Nochi - Microorganisms, 2021 - mdpi.com
Bile acids (BAs) are produced from cholesterol in the liver and are termed primary BAs.
Primary BAs are conjugated with glycine and taurine in the liver and then released into the …

Bile acids and their receptors in regulation of gut health and diseases

S Lin, S Wang, P Wang, C Tang, Z Wang… - Progress in Lipid …, 2023 - Elsevier
It is well established that bile acids play important roles in lipid metabolism. In recent
decades, bile acids have also been shown to function as signaling molecules via interacting …

Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

JS Fleishman, S Kumar - Signal Transduction and Targeted Therapy, 2024 - nature.com
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …

Bile acids—A peek into their history and signaling

JT Nguyen, RPH Shaw, S Anakk - Endocrinology, 2022 - academic.oup.com
Bile acids wear many hats, including those of an emulsifier to facilitate nutrient absorption, a
cholesterol metabolite, and a signaling molecule in various tissues modulating itching to …

The role of bile acids in regulating glucose and lipid metabolism

H Yu, R Nie, C Shen - Endocrine Journal, 2023 - jstage.jst.go.jp
In recent years, bile acids (BAs) are increasingly being appreciated as signaling molecules
beyond their involvement in bile formation and fat absorption. The farnesoid X receptor …

A recent ten-year perspective: bile acid metabolism and signaling

Y Shulpekova, E Shirokova, M Zharkova, P Tkachenko… - Molecules, 2022 - mdpi.com
Bile acids are important physiological agents required for the absorption, distribution,
metabolism, and excretion of nutrients. In addition, bile acids act as sensors of intestinal …

Bile acids-gut microbiota crosstalk contributes to the improvement of type 2 diabetes mellitus

R Gao, X Meng, Y Xue, M Mao, Y Liu, X Tian… - Frontiers in …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) occurs that cannot effectively use the insulin. Insulin
Resistance (IR) is a significant characteristic of T2DM which is also an essential treatment …

Metabolic messengers: bile acids

A Perino, K Schoonjans - Nature metabolism, 2022 - nature.com
Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on
both host and microbial metabolism. These metabolites have emerged as biologically active …

Metabolic effects of bile acids in the gut in health and disease

M Boesjes, G Brufau - Current medicinal chemistry, 2014 - ingentaconnect.com
In the last decade, it became clear that bile acids, in addition to their role in intestinal
absorption of lipids and fat-soluble vitamins, are major regulators of metabolism. They …