Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

The advent of cancer immunotherapy has revolutionized the field of cancer treatment and
offers cancer patients new hope. Although this therapy has proved highly successful for …

Treating cancer with vaccines has been a challenging field of investigation since the 1950s.
Over the years, the lack of effective active immunotherapies has led to the development of …

Cancer vaccines have been shown clinically to drive tumor-reactive cell activation,
proliferation, and effector function. Unfortunately, tumor eradication by treatment with cancer …

There are strong biologic and preclinical rationales for the development of therapeutic
cancer vaccines; however, the clinical translation of this treatment strategy has been …

Background: Cancer vaccines are a unique approach to cancer therapy. They exert an
antitumor effect by engaging the host immune response, and have great potential for …

Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

With the development and regulatory approval of immune checkpoint inhibitors and adoptive
cell therapies, cancer immunotherapy has undergone a profound transformation over the …

The development of therapeutic cancer vaccines has been pursued for many decades.
Many vaccines can elicit immunity to tumour antigens, although their clinical efficacy …

The therapeutic potential of host-specific and tumour-specific immune responses is well
recognized and, after many years, active immunotherapies directed at inducing or …