Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21)
A Amini, A Ehteda, S Masoumi Moghaddam… - OncoTargets and …, 2013 - Taylor & Francis
Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …
arising from interaction with a number of different biological processes. Several preclinical …
Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives
K Chobotova, AB Vernallis, FAA Majid - Cancer letters, 2010 - Elsevier
The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …
Bromelain-induced apoptosis in GI-101A breast cancer cells
S Dhandayuthapani, HD Perez, A Paroulek… - Journal of medicinal …, 2012 - liebertpub.com
Bromelain is a proteolytic enzyme extracted from the stems and the immature fruits of
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …
Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy
A Amini, S Masoumi-Moghaddam, A Ehteda… - Journal of Experimental …, 2014 - Springer
Background Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing
compounds with good safety profiles which have been investigated for their benefits and …
compounds with good safety profiles which have been investigated for their benefits and …
Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
TC Chang, PL Wei, PT Makondi, WT Chen, CY Huang… - PloS one, 2019 - journals.plos.org
Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …
and targeted therapies. The development of new effective or alternative therapies is …
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects
Scope Colorectal cancer is an important health problem across the world. Here, we
investigated the possible antiproliferative/proapoptotic effects of bromelain (from the …
investigated the possible antiproliferative/proapoptotic effects of bromelain (from the …
Anticancer properties of bromelain: State-of-the-art and recent trends
Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic
substance with multiple beneficial effects for human health such as anti-inflammatory …
substance with multiple beneficial effects for human health such as anti-inflammatory …
Bromelain inhibits nuclear factor kappa‐B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis
K Bhui, S Tyagi, AK Srivastava, M Singh… - Molecular …, 2012 - Wiley Online Library
Bromelain, obtained from pineapple, is already in use clinically as adjunct in chemotherapy.
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …
Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
N Kalra, K Bhui, P Roy, S Srivastava, J George… - Toxicology and applied …, 2008 - Elsevier
Bromelain is a pharmacologically active compound, present in stems and immature fruits of
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti …
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti …
Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway
H Zhang, Y Jiao, C Shi, X Song, Y Chang, Y Ren, X Shi - Cytotechnology, 2018 - Springer
Berbamine has been shown to exhibit anti-cancer activities in various types of cancers. The
effects of berbamine on colorectal colon cancer (CRC) have not been examined, and the …
effects of berbamine on colorectal colon cancer (CRC) have not been examined, and the …