Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21)

A Amini, A Ehteda, S Masoumi Moghaddam… - OncoTargets and …, 2013 - Taylor & Francis
Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …

Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives

K Chobotova, AB Vernallis, FAA Majid - Cancer letters, 2010 - Elsevier
The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

Bromelain-induced apoptosis in GI-101A breast cancer cells

S Dhandayuthapani, HD Perez, A Paroulek… - Journal of medicinal …, 2012 - liebertpub.com
Bromelain is a proteolytic enzyme extracted from the stems and the immature fruits of
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …

Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy

A Amini, S Masoumi-Moghaddam, A Ehteda… - Journal of Experimental …, 2014 - Springer
Background Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing
compounds with good safety profiles which have been investigated for their benefits and …

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

TC Chang, PL Wei, PT Makondi, WT Chen, CY Huang… - PloS one, 2019 - journals.plos.org
Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …

The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects

B Romano, I Fasolino, E Pagano… - Molecular nutrition & …, 2014 - Wiley Online Library
Scope Colorectal cancer is an important health problem across the world. Here, we
investigated the possible antiproliferative/proapoptotic effects of bromelain (from the …

Anticancer properties of bromelain: State-of-the-art and recent trends

R Pezzani, M Jimenez-Garcia, X Capo… - Frontiers in …, 2023 - frontiersin.org
Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic
substance with multiple beneficial effects for human health such as anti-inflammatory …

Bromelain inhibits nuclear factor kappa‐B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis

K Bhui, S Tyagi, AK Srivastava, M Singh… - Molecular …, 2012 - Wiley Online Library
Bromelain, obtained from pineapple, is already in use clinically as adjunct in chemotherapy.
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …

Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin

N Kalra, K Bhui, P Roy, S Srivastava, J George… - Toxicology and applied …, 2008 - Elsevier
Bromelain is a pharmacologically active compound, present in stems and immature fruits of
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti …

Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway

H Zhang, Y Jiao, C Shi, X Song, Y Chang, Y Ren, X Shi - Cytotechnology, 2018 - Springer
Berbamine has been shown to exhibit anti-cancer activities in various types of cancers. The
effects of berbamine on colorectal colon cancer (CRC) have not been examined, and the …