A growing body of literature reports on the upregulation of CXC motif chemokine receptor 4
(CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for …

Chemokines (CK) s, small proinflammatory chemoattractant cytokines that bind to specific G-
protein coupled seven-span transmembrane receptors, are major regulators of cell …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

The chemokine stromal cell–derived factor 1 (SDF-1) is essential for perinatal viability, B
lymphopoiesis, and bone marrow myelopoiesis, and is a potent monocyte and T-lymphocyte …

The chemokine receptor, CXCR4, is involved in cancer growth, invasion, and metastasis.
Several promising CXCR4 antagonists have been shown to halt tumor metastasis in …

Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells,
and cause tissue extravasation. Given these properties, their role in anti-tumor immune …

Cancer is a leading cause of death worldwide and imposes a substantial financial burden.
Therefore, it is essential to develop cost-effective approaches to inhibit tumor growth and …

Background Resident memory T lymphocytes (T RM) are located in tissues and play an
important role in immunosurveillance against tumors. The presence of T RM prior to …

It is well-established that the chemokine CXC motif ligand 13 (CXCL13) and its receptor, the
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …

Cancer metastasis is a major clinical problem that contributes to unsuccessful therapy.
Augmenting evidence indicates that metastasizing cancer cells employ several mechanisms …