The objective of this study was to examine whether the effects of age-related
neuropathologies on cognition change over time. Participants were 1096 deceased persons …

The ageing brain is vulnerable to a wide array of neuropathologies. Prior work estimated
that the three most studied of these, Alzheimer's disease, infarcts, and Lewy bodies, account …

The association of dementia-related pathologies with cognition is hypothesized to decrease
as age advances. We examined this in 413 persons without cognitive impairment at …

Objective: Neurodegenerative and cerebrovascular conditions are common in old age and
are associated with cognitive decline. However, considerable heterogeneity remains in …

Objective To assess whether neurodegenerative pathologies are differentially related to
trajectories of change in different cognitive abilities. Methods At annual intervals for up to 21 …

Objective To characterize trajectories of normative cognitive aging. Methods Older persons
without dementia at study enrollment (n= 1,010) had annual cognitive testing for up to 24 …

Objective: To test the hypothesis that rate of cognitive decline accelerates in the last years of
life. Methods: Participants are 853 older persons without dementia at study onset. For up to 8 …

Objective: To test the hypothesis that different forms of neurodegeneration are differentially
related to longitudinal cognitive trajectories in old age. Methods: Participants are 420 older …

Objective The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy
body disease accumulate in the brains of older persons with and without dementia, but the …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …