The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …

Abstract Purpose of Review Locus coeruleus (LC) is the main noradrenergic nucleus of the
brain, and its degeneration is considered to be key in the pathogenesis of …

Locus Coeruleus (LC) is the main noradrenergic nucleus of the brain, which is involved in
many physiological functions including cognition; its impairment may be crucial in the …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Background and purpose Human neuropathological studies indicate that the pontine
nucleus Locus Coeruleus (LC) undergoes significant and early degeneration in Alzheimer's …

The locus coeruleus (LC) is a brainstem nucleus involved in important cognitive functions.
Recent developments in neuroimaging methods and scanning protocols have made it …

Locus Coeruleus (LC) is the main noradrenergic nucleus of the central nervous system, and
its neurons widely innervate the whole brain. LC is severely degenerated both in …

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, may play an important role in neuropsychiatric disorders including …

Early and profound pathological changes are evident in the locus coeruleus (LC) in
dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor …

The brainstem locus coeruleus (LC) influences a broad range of brain processes, including
cognition. The so-called LC contrast is an accepted marker of the integrity of the LC that …