Abstract Background: The t (14; 18)(q32; q21) translocation is the most commonly observed
chromosomal translocation in non–Hodgkin's lymphoma (NHL), resulting in constitutive Bcl …

BACKGROUND: Many strategies are being used for the quest for the disease causing
genes. Inter-individual variations in several genes exist. Thus, even if they share the same …

Failure of apoptosis is one of the hallmarks of cancer. As an execution-phase caspase,
caspase-3 plays a crucial role during apoptosis. To explore the possibility that the genetic …

Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding RNAs that are
involved in a wide variety of biological processes. There are limited data regarding the …

Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a
defence against cancer. The CASP8 polymorphism D302H has recently been shown to …

Caspases are important regulators and executioners in the apoptosis pathways and play
crucial roles in carcinogenesis. We tested the hypothesis that functional variants of CASP …

Genetic polymorphisms in the promoter regions of FAS, FASL and CASP 8 involved in the
apoptotic signaling pathway are thought to be associated with susceptibility to cancer. We …

Background CASR gene appears to be involved in cancer biology and physiology.
However, a number of studies investigating CASR polymorphisms and cancer risks have …

Genetic factors are widely recognized to have a substantial effect on the susceptibility to
rheumatoid arthritis (RA). We examined the contribution of caspase-5 (CASP5) gene …

Background Dysregulation of apoptosis plays a crucial role in carcinogenesis. Our aim was
to investigate the association of Caspase 9 and Caspase 8 gene polymorphism with bladder …