Studies on the interactions of tobacco leaf and tobacco smoke constituents and monoamine oxidase

K Castagnoli, SJ Steyn, G Magnin… - Neurotoxicity …, 2002 - Springer
Studies have demonstrated that smokers have lower levels of brain monoamine oxidase
(MAO) A and B activity and lower MAO-B platelet activity than non-smokers. Recent …

Inhibition of human MAO-A and MAO-B by a compound isolated from flue-cured tobacco leaves and its neuroprotective properties in the MPTP mouse model of …

K Castagnoli, JB Petzer, SJ Steyn… - …, 2003 - Springer
Prompted by the findings that smokers have lowered brain and blood platelet monoamine
oxidase-A and-B activities compared to non-smokers and that smokers have a lowered …

Tobacco leaf, smoke and smoking, MAO inhibitors, Parkinson's disease and neuroprotection; are there links?

K Castagnoli, T Murugesan - Neurotoxicology, 2004 - Elsevier
The potential neuroprotective properties of monoamine oxidase B (MAO-B) inhibitors have
been of interest in part because of the role that this enzyme plays in the bioactivation of the …

Neuroprotection in the MPTP Parkinsonian C57BL/6 mouse model by a compound isolated from tobacco

KP Castagnoli, SJ Steyn, JP Petzer… - Chemical research in …, 2001 - ACS Publications
Epidemiological evidence suggests a lower incidence of Parkinson's disease in smokers
than in nonsmokers. This evidence, together with the lower levels of brain monoamine …

Monoamine oxidase and cigarette smoking

JS Fowler, J Logan, GJ Wang, ND Volkow - Neurotoxicology, 2003 - Elsevier
Current cigarette smokers have reduced monoamine oxidase (MAO) and there is evidence
that this is a pharmacological effect of tobacco smoke exposure rather than a biological …

Human monoamine oxidase is inhibited by tobacco smoke: β-carboline alkaloids act as potent and reversible inhibitors

T Herraiz, C Chaparro - Biochemical and biophysical research …, 2005 - Elsevier
Monoamine oxidase (MAO) is a mitochondrial outer-membrane flavoenzyme involved in
brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines …

Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition

JS Fowler, ND Volkow, GJ Wang… - Journal of Addictive …, 1998 - Taylor & Francis
We measured the concentration of brain monoamine oxidase B (MAO B; EC 1.4. 3.4) in 8
smokers and compared it with that in 8 non-smokers and in 4 former smokers using positron …

Isolation and characterization of a monoamine oxidase inhibitor from tobacco leaves

AA Khalil, S Steyn, N Castagnoli - Chemical research in toxicology, 2000 - ACS Publications
Recent positron emission tomography imaging studies have demonstrated a significant
decrease in both monoamine oxidase A and B (MAO-A and MAO-B) activities in the brains of …

Monoamine oxidases and tobacco smoking

I Berlin, R M. Anthenelli - International Journal of …, 2001 - academic.oup.com
Although nicotine has been identified as the main ingredient in tobacco responsible for
aspects of the tobacco dependence syndrome, not all of the psychopharmacological effects …

Contribution of monoamine oxidase inhibition to tobacco dependence: a review of the evidence

RC Hogg - Nicotine & Tobacco Research, 2016 - academic.oup.com
Background: There is a hypothesis that substances present in, or derived from, tobacco
smoke inhibit monoamine oxidase (MAO) in the brains of smokers, reducing the degradation …