The design of artificial enzymes has emerged as a promising tool for the generation of
potent biocatalysts able to promote new-to-nature reactions with improved catalytic …

Artificial enzymes based on the modification of a protein structure for the creation of new
active catalytic sites have experienced a great boom in recent years. Multidisciplinary …

Fundamental research into bioinorganic catalysis of the kind presented at this Faraday
Discussion has the potential to turn inspiration drawn from impressive natural energy and …

Astonishing progress has been achieved in unlocking new‐to‐nature biocatalysis in the past
decades. The progress in protein engineering enabled research to efficiently incorporate …

Recent development in biochemical experiment techniques and bioinformatics has enabled
us to create a variety of artificial biocatalysts with protein scaffolds (namely 'artificial …

Highlights•The most recent developments of de novo enzyme design (methodologies and
applications) are reported.•The different chemical reactions for which de novo enzymes …

Contemporary Biocatalysis heavily relies on enzyme engineering as natural enzymes
frequently lack the requisite attributes for effective organic synthesis. The inherent limitations …

Protein engineering has emerged as a straightforward and efficient strategy to expand the
application fields of natural enzymes as biocatalysts. It has developed rapidly depending on …

The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

Enzymes offer cheap, environmentally responsible and highly efficient alternatives to
chemical catalysts. The past two decades have seen a significant rise in the use of enzymes …