Plague is transmitted by fleas or contaminated aerosols. To successfully produce disease,
the causal agent (Yersinia pestis) must rapidly sense and respond to rapid variations in its …

The flea's lumen gut is a poorly documented environment where the agent of flea‐borne
plague, Yersinia pestis, must replicate to produce a transmissible infection. Here, we report …

Human polymorphonuclear leukocytes (PMNs, or neutrophils) are the most abundant innate
immune cell and kill most invading bacteria through combined activities of reactive oxygen …

YopM, a protein toxin of Yersinia pestis, is necessary for virulence in a mouse model of
systemic plague. We previously reported YopM-dependent natural killer (NK) cell depletion …

Abstract Background The transcription regulator PhoP has been shown to be important for Y.
pestis survival in macrophages and under various in vitro stresses. However, the …

Yersinia pestis, the causative agent of plague, is transmitted among mammals (including
humans) primarily via the bite of infected fleas. Flea-borne transmission distinguishes Y …

We are using a systemic plague model to identify the cells and pathways that are
undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this …

Bubonic plague (a fatal, flea-transmitted disease) remains an international public health
concern. Although our understanding of the pathogenesis of bubonic plague has improved …

Abstract Background The osmotic regulator OmpR in Escherichia coli regulates differentially
the expression of major porin proteins OmpF and OmpC. In Yersinia enterocolitica and Y …

The two-component regulatory system PhoPQ has been identified in many bacterial species.
However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria …