TGF-β1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression

Y Huang, Y Xie, PW Abel, P Wei, J Plowman… - Biochemical …, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with irreversible
loss of lung tissue and function. Myofibroblasts in the lung are key cellular mediators of IPF …

Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis

P Wei, Y Xie, PW Abel, Y Huang, Q Ma, L Li, J Hao… - Cell death & …, 2019 - nature.com
Transforming growth factor (TGF)-β1, a main profibrogenic cytokine in the progression of
idiopathic pulmonary fibrosis (IPF), induces differentiation of pulmonary fibroblasts to …

The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis

X Chen, C Shi, C Wang, W Liu, Y Chu, Z Xiang, K Hu… - Scientific reports, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrotic lung disease
characterized by profound changes in stem cell differentiation, epithelial cell phenotypes …

miR-338-3p blocks TGFβ-induced myofibroblast differentiation through the induction of PTEN

AR Rackow, JL Judge, CF Woeller… - … of Physiology-Lung …, 2022 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease. The pathogenesis of
IPF is not completely understood. However, numerous genes are associated with the …

The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis

C Liang, X Li, L Zhang, D Cui, X Quan… - … and Molecular Pathology, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial fibrotic lung disease with an
undefined etiology and no effective treatments. By binding to cell surface receptors …

IPF-fibroblast Erk1/2 activity is independent from microRNA cluster 17-92 but can be inhibited by treprostinil through DUSP1

S Blumer, L Fang, WC Chen, P Khan, K Hostettler… - Cells, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive terminal lung disease, and therapies aim
to block fibrosis. Fibroblast proliferation is controlled by C/EBP-β, microRNA cluster 17-92 …

MicroRNA-326 regulates profibrotic functions of transforming growth factor-β in pulmonary fibrosis

S Das, M Kumar, V Negi, B Pattnaik… - American journal of …, 2014 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a fatal disorder resulting from the progressive
remodeling of lungs, with no known effective treatment. Although transforming growth factor …

miR‐19a,‐19b, and‐26b mediate CTGF expression and pulmonary fibroblast differentiation

YC Chen, BC Chen, CC Yu, SH Lin… - Journal of cellular …, 2016 - Wiley Online Library
Although microRNA (miRNA) dysregulation with intracellular signaling cascade disruption
has been demonstrated in the pathophysiology of pulmonary fibrosis, the relationship …

Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells

C Wang, H Cao, S Gu, C Shi, X Chen, X Han - Differentiation, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a serious lung disease that involved the myofibroblast
differentiation of lung resident mesenchymal stem cells (LR-MSCs). However, the specific …

Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition

X Xiao, C Huang, C Zhao, X Gou… - Archives of biochemistry …, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is one of the most common and severe interstitial lung
diseases. Epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cells …