Safety aspects of treatment with lacidipine—a slow-onset, long-acting calcium antagonist

LH Lindholm, P Tcherdakoff, A Zanchetti - Blood pressure, 1996 - Taylor & Francis
Objective: The aim was to review the clinical safety profile of lacidipine with the help of the
rather comprehensive datafile of the manufacturer-a novel approach which may be of some …

Safety of the calcium antagonist lacidipine evaluated from a phase III–IV trial database

LH Lindholm, P Tcherdakoff… - Journal of Hypertension, 1996 - journals.lww.com
Objective We reviewed the clinical safety profile of lacidipine with the help of the rather
comprehensive data file of the manufacturer. Although a number of prospective, randomly …

Safety profile of lacidipine: a review of clinical data

CA Endersby, EG Brown… - Journal of cardiovascular …, 1991 - journals.lww.com
The clinical safety of the new dihydropyridine calcium antagonist lacidipine was assessed in
14 clinical trials, including 1,372 patients treated with lacidipine and 687 treated with an …

Long-term antihypertensive treatment with lacidipine, a new long-acting calcium antagonist

R Nami, P Rizzini, P Buracchi, G Pavese… - Journal of …, 1991 - journals.lww.com
Eleven centers in Tuscany, Italy, recruited 96 patients (aged 21-75 years) with mild-to-
moderate essential hypertension [diastolic blood pressure (DBP) 95-115 mm Hg; systolic …

Selection of initial and maintenance dosages for lacidipine, a new once-daily calcium antagonist for the treatment of hypertension

M Perelman - Journal of cardiovascular pharmacology, 1991 - journals.lww.com
Selection of the appropriate dose of a new drug for initiation of treatment and then for
maintenance is a complicated task. It requires the careful assessment and weighing of …

Lacidipine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of hypertension

C Rhoda Lee, HM Bryson - Drugs, 1994 - Springer
Synopsis Lacidipine is an orally administered calcium channel blocker of the
dihydropyridine class, which shows selectivity for vascular smooth muscle over cardiac …

French large-scale study evaluating the tolerability and efficacy of lacidipine

P Tcherdakoff - Journal of Cardiovascular Pharmacology, 1995 - journals.lww.com
In a large, open, multicenter study, 2,206 outpatients with mild-to-moderate essential
hypertension were recruited by 755 cardiologists throughout France. Patients received …

Lacidipine: a review of its use in the management of hypertension

PL McCormack, AJ Wagstaff - Drugs, 2003 - Springer
Summary Abstract Lacidipine (Caldine®, Lacimen®, Lacipil®, Midotens®, Motens®) is a
once-daily, orally-administered, lipophilic dihydropyridine calcium antagonist with an …

A long-term study comparing lacidipine and nifedipine SR in hypertensive patients: safety data

G Leonetti, S Salvi - Journal of Cardiovascular Pharmacology, 1994 - journals.lww.com
The clinical safety of lacidipine, a new dihydropyridine calcium antagonist, has been
assessed in a longterm, comparative study in hypertensive patients. Slowrelease (SR) …

Clinical position of lacidipine, a new dihydropyridine calcium antagonist, in the treatment of hypertension

G Leonetti - Journal of cardiovascular pharmacology, 1991 - journals.lww.com
Lacidipine is a calcium antagonist of the dihydropyridine group that is highly selective for
vascular tissues. It has been tested during the last few years for the treatment of arterial …