The calcium antagonists of the dihydropyridine group, isradipine and nifedipine, were
compared in 64 patients with mild to moderate hypertension (diastolic blood pressure 95 to …

Calcium antagonists (CaAs) are divided into three structural classes, typically represented
by verapamil, diltiazem and nifedipine. As a group, the principal (type I) adverse effects of …

The purpose of the present study was to evaluate the efficacy and tolerability of lercanidipine
vs. placebo in patients with mild to moderate essential hypertension. A randomized, double …

This symposium on calcium antagonists for antihypertensive baseline therapy was
overshadowed by the sudden death of Franz Gross in his Basel home on March 26, 1984 …

The antihypertensive efficacy and tolerability of the new calcium antagonist isradipine was
assessed in 86 hypertensive patients who had pretreatment diastolic blood pressures …

Isolated systolic hypertension (ISH) is a definite risk factor for cardiovascular complications
(ie, cardiac failure, coronary artery disease, and stroke) independent of diastolic elevation …

Calcium channel antagonists have become popular medications for the management of
hypertension. These agents belong to the diphenylalkylamine, benzothiazepine …

The long-term tolerability and antihypertensive effect of lercanidipine, a new calcium-entry
blocker, was evaluated in this open, multicenter study. A total of 355 mild to moderately …

Pharmacokinetic data are important in the development of rational regimens for drug
administration, particularly for agents with the potential for serious toxicity …

The TOLERANCE study was aimed to compare the tolerability of high doses of lercanidipine
(20 mg) with that of other frequently used dihydropyridines (amlodipine 10 mg/nifedipine …