K+ channels in heart can be subdivided into two groups, voltage-operated and ligand-
operated channels. Only the voltage-operated channels—i K, i to, and i K1—and one ligand …

Ideas about K+ channels in cardiac cells have changed since the time when attempts were
made to explain the cardiac action potential by only two essential currents: an activating …

Potassium channel currents are important in maintaining the normal electrical activity in
most excitable cells. This family of channels controls the cell resting potential and action …

T he search for new antiarrhythmic agents has long centered around drugs capable of
inhibiting one or more of theionic currents responsible for transmembrane activity in cardiac …

We applied the cell-attached and inside-out patch-clamp technique under symmetrical
isotonic potassium conditions on single human (and guinea pig) atrial cells. The human …

1. In rabbit and human hearts there are significant differences in the action potential
configuration in atrium and ventricle, and the action potential waveform exhibits marked …

The contribution of Na+, Ca2+, and various K+ currents to the shape of the cardiac action
potential is outlined based on the relation between electrophysiological properties and …

The results with the K+ channel blocking compounds are encouraging because they show a
slight structural change in a parent blocking compound can dramatically alter the type of K+ …

ATP-dependent decay and recovery of the inward rectifier and ATP-sensitive K+ channels
were investigated using inside-out patch recording in cardiac myocytes. The solution facing …

Myocardial K+ currents function to control resting membrane potentials, the heights and
durations of action potentials, and refractoriness and automaticity. They are important targets …