The multifaceted role of CD4+ T cells in CD8+ T cell memory
Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …
Shaping and reshaping CD8+ T-cell memory
JT Harty, VP Badovinac - Nature Reviews Immunology, 2008 - nature.com
The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …
immunization is a hallmark of the adaptive immune response and a basis for protective …
Memory CD4 T cells: generation, reactivation and re‐assignment
MKL MacLeod, JW Kappler, P Marrack - Immunology, 2010 - Wiley Online Library
Immunological memory is one of the features that define the adaptive immune response: by
generating specific memory cells after infection or vaccination, the host provides itself with a …
generating specific memory cells after infection or vaccination, the host provides itself with a …
Surviving the crash: transitioning from effector to memory CD8+ T cell
LM D'Cruz, MP Rubinstein, AW Goldrath - Seminars in immunology, 2009 - Elsevier
One outcome of infection is the formation of long-lived immunological memory, which
provides durable protection from symptomatic re-infection. In response to infection or …
provides durable protection from symptomatic re-infection. In response to infection or …
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection
JC Sun, MA Williams, MJ Bevan - Nature immunology, 2004 - nature.com
Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …
deficient recall responses and diminished protective immunity. Here we investigated at what …
Developing and maintaining protective CD8+ memory T cells
MA Williams, BJ Holmes, JC Sun… - Immunological …, 2006 - Wiley Online Library
A critical aim of vaccine‐related research is to identify the mechanisms by which memory T
cells are formed and maintained over long periods of time. In recent years, we have …
cells are formed and maintained over long periods of time. In recent years, we have …
The descent of memory T-cell subsets
L Lefrançois, AL Marzo - Nature Reviews Immunology, 2006 - nature.com
The immune system has evolved by continuously increasing its complexity to provide the
host with an advantage over infectious agents. The development of immunological memory …
host with an advantage over infectious agents. The development of immunological memory …
Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation
The developmental pathways of long-lived memory CD8 T cells and the lineage relationship
between memory T cell subsets remain controversial. Although some studies indicate the …
between memory T cell subsets remain controversial. Although some studies indicate the …
Requirements for CD8 T-cell priming, memory generation and maintenance
M Prlic, MA Williams, MJ Bevan - Current opinion in immunology, 2007 - Elsevier
Immunological memory is characterized by the ability to provide protection from secondary
exposure to pathogens. CD8+ memory T cells provide protection from cell-associated …
exposure to pathogens. CD8+ memory T cells provide protection from cell-associated …
Molecular and functional profiling of memory CD8 T cell differentiation
How and when memory T cells form during an immune response are long-standing
questions. To better understand memory CD8 T cell development, a time course of gene …
questions. To better understand memory CD8 T cell development, a time course of gene …