Carcinomas typically invade as a cohesive multicellular unit, a process termed collective
invasion. It remains unclear how different subpopulations of cancer cells contribute to this …

Tumor cells can engage in a process called collective invasion, in which cohesive groups of
cells invade through interstitial tissue. Here, we identified an epigenetically distinct …

The majority of human breast cancers exhibit luminal epithelial differentiation. However,
most aggressive behavior, including invasion and purported cancer stem cell activity, are …

Collective invasion into adjacent tissue is a hallmark of luminal breast cancer, and~ 20% of
these cases eventually undergo metastasis. How less aggressive luminal-like breast cancer …

Highlights•Cancer invasion is accomplished through interactions among distinct cell
types.•Both epithelial–epithelial and epithelial–stromal interactions regulate …

Most invasive solid tumours display predominantly collective invasion, in which groups of
cells invade the peritumoral stroma while maintaining cell–cell contacts. As the concepts …

A critical step in breast cancer progression is local tissue invasion, during which cells pass
from the epithelial compartment to the stromal compartment. We recently showed that …

Carcinoma dissemination can occur when heterogeneous tumor and tumor-stromal cell
clusters migrate together via collective migration. Cells at the front lead and direct collective …

Breast cancer undergoes collective tissue invasion and, in experimental models, can
collectively metastasize. The prevalence of collective invasion and its contribution to distant …

Cancer invasion programs are adaptive by switching between metastatic collective and
single-cell dissemination; however, current intravital microscopy models for epithelial cancer …