Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix
calcium and is characterized by the opening of the PT pore (PTP). Activation of the PTP …

Autophagy is a highly regulated intracellular degradation process by which cells remove
cytosolic long-lived proteins and damaged organelles. The mitochondrial permeability …

The mitochondrial permeability transition pore (MPTP) plays a key role in cell death, yet its
molecular identity remains uncertain. Although knock-out studies have confirmed critical …

1112 ELROD JW et al. red-sensitive mechanism (now known to be the mitochondrial
calcium uniporter (MCU), the genetic identity of which was recently discovered14–16) and …

Cyclophilin D (CypD, encoded by Ppif) is an integral part of the mitochondrial permeability
transition pore, whose opening leads to cell death. Here we show that interaction of CypD …

Cardiac failure is a leading cause of age-related death, though its root cause remains
unknown. Mounting evidence implicates a decline in mitochondrial function due to …

Cyclosporin A (CsA) inhibits opening of the mitochondrial permeability transition pore
(MPTP), a critical event in some forms of necrotic and apoptotic cell death, by binding to …

Despite the lack of its molecular identification, the mitochondrial permeability transition pore
(PTP) is a fascinating subject because of its important role in cell death. This holds …

The major underpinning of massive cell death associated with myocardial infarction involves
opening of the mitochondrial permeability transition pore (mPTP), resulting in disruption of …

Background Opening of the mitochondrial permeability transition pore is the underlying
cause of cellular dysfunction during diverse pathological situations. Although this …