Mitochondria isolated from synaptosomes are more sensitive to Ca2+ overload and the
resultant opening of the mitochondrial permeability transition pore (mPTP) than nonsynaptic …

An imbalance in mitochondrial dynamics induced by oxidative stress may lead to hepatocyte
epithelial mesenchymal transition (EMT) and liver fibrosis. However, the underlying …

Regulation of mitochondrial free Ca2+ is critically important for cellular homeostasis. An
increase in mitochondrial matrix free Ca2+ concentration ([Ca2+] m) predisposes …

Mitochondria are a principal site for generation of reactive oxygen species (ROS) in the
heart. Peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α) plays an …

A critical question related to the deactivation of mitochondrial metabolism in heart failure is
whether such energy metabolic abnormalities contribute to the pathology of, or are …

genes and transcription factors, and promoting stem cell cardiac differentiation. 20–22 Such
cardiogenic effects appear to be concentration-dependent, as high levels of ROS can delay …

Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for
growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier …

Background and purpose: We have investigated the therapeutic effects of the selective
cyclophilin inhibitor D‐MeAla3‐EtVal4‐cyclosporin (Debio 025) in myopathic Col6a1 …

The myocardium is metabolically flexible; however, impaired flexibility is associated with
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …