Background The overexpression of the cholesterol transporter: ATP-binding cassette
transporter (ABCG8) due to the effect of ABCG8 genetic variant (rs11887534) leads to the …

Abstract Background and Aim: Gallstone formation is characterized by the abnormal
regulation of cholesterol trafficking and solubilization. The prevalence of gallstone disease …

Background Adenosine triphosphate-binding cassette (ABC) transporters ABCG5 and
ABCG8 are sterol export pumps regulating biliary cholesterol excretion. The formation of …

Abstract Background and Aim: The excretion of cholesterol from the liver is regulated by the
ATP‐binding cassette transporter ABCG8. A common genetic polymorphism D19H of …

Background Gallstones are abnormal masses caused by impaired metabolism of
cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette …

BACKGROUND: Supersaturation of bile with cholesterol is a primary step in the formation of
cholesterol gallstones. ATP binding cassette (ABC) G5 and G8 play an important role in …

Genomewide scans of inbred strains of mice have linked the genes encoding the
hepatocanalicular cholesterol transporter ABCG5/G8 to gallstone formation. Five …

Background Gallstone disease (GD) is common but remains asymptomatic in most cases.
However, gallstones can lead to complications like choledocholithiasis or gallbladder …

Background In this study, we evaluated the association between these polymorphisms and
gallstone disease using meta-analysis and compared the hepatic ABCG5/G8 mRNA …

BACKGROUND: The role of ABCG5 and ABCG8 genes in the determination of plasma lipid
levels is currently under intensive investigation. The aim of this study was to evaluate …