Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and
can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the …

Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor
post-surgical course after curative surgery. However, biomarkers stratifying this high-risk …

Simple Summary Considering that cancer-associated fibroblasts (CAFs) facilitate cancer cell
motility, invasiveness, and drug resistance, heterogeneity within the CAF population may be …

Cancer-associated fibroblasts (CAFs) are highly heterogeneous. With the lack of a
comprehensive understanding of CAFs' functional distinctions, it remains unclear how …

Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity
is maintained in vivo is unclear and is difficult to study in vitro. Here we establish a …

Simple Summary In the tumor microenvironment, cancer-associated fibroblasts (CAFs) have
multiple tumor-promoting functions in drug resistance, regulation of the niche of cancer stem …

It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell
exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing …

The tumor microenvironment strongly influences cancer development, progression, and
metastasis. The role of carcinoma-associated fibroblasts (CAFs) in these processes and …

Cancer-associated fibroblasts (CAFs) have been shown to enhance squamous cell
carcinoma (SCC) growth, but it is unclear whether they promote SCC lung metastasis. We …

Carcinoma-associated fibroblasts (CAFs) are abundant stromal cells in tumor
microenvironment that are critically involved in cancer progression. Contrasting reports have …