The aim of the present study was to evaluate the benefit of monitoring serum piperacillin
concentrations in critically ill patients. This was an 11-month, prospective, observational …

Objective To explore the effects of renal function estimated by measured creatinine
clearance (Cl CR) on trough serum concentration (C min) of piperacillin given to critically ill …

Therapeutic drug monitoring for critically ill patients receiving piperacillin/tazobactam is
described as a useful tool. However, the minimum inhibitory concentration of piperacillin …

Background Piperacillin levels after standard dosing have been shown frequently to be
subtherapeutic, especially when renal clearance was augmented. Here, we aimed to …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Objective: To describe a pharmacokinetic model of piperacillin concentrations in plasma and
subcutaneous tissue when administered by bolus dosing and continuous infusion in …

Since the bactericidal effects of β-lactam antibiotics are time dependent, the optimum
strategy for their administration could be continuous infusion. In this prospective …

Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the
unpredictable pharmacokinetic profile of this patient population. Several studies have shown …

The study aimed to evaluate saturation of piperacillin elimination in critically ill adult patients.
Seventeen critically ill adult patients received continuous and intermittent infusion of …

This retrospective cohort study included 53 patients admitted to the intensive care unit (ICU),
with an average age of 69 years, without neurologic disorder before initiation of a …