RATIONALE: Granzyme K (GZMK)-positive CD8+ T cells are a subset of cytotoxic
lymphocytes that accumulate in the peripheral blood and tissues of aged mice. These cells …

A novel population of age-associated Granzyme K (GZMK)-expressing CD8 T cells was
found in mice and humans. These cells enhance local tissue senescence and inflammation …

Granzymes are a family of serine-proteases that act as critical mediators in the cytolytic and
immunomodulatory activities of immune cells such as CD8+ T-cells and natural killer (NK) …

Abstract NK cells and CD8 T cells use cytotoxic molecules to kill virally infected and tumor
cell targets. While perforin and granzyme B (GzmB) are the most commonly studied lytic …

Results CD4+ CD25 high cells percentage and cytoplasmic forkhead box protein P3
expression were significantly lower in COPD compared with healthy controls, either …

GZMK+ T cells a hallmark of immune ageing | Nature Reviews Immunology Skip to main
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Background: Chronic obstructive pulmonary disease (COPD) is often accompanied by
intestinal symptoms. Myeloid-derived suppressor cells (MDSCs) possess …

Background Expression of glycoprotein A dominant repeat (GARP) has been reported to
occur only in activated human naturally occurring regulatory T cells (Tregs) and their clones …

Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of
chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T …

Background Lung inflammation plays a vital role in the pathogenesis of chronic obstructive
pulmonary disease (COPD), but the characteristics of the inflammatory process remain …